PMID- 19192340
OWN - NLM
STAT- MEDLINE
DCOM- 20090501
LR  - 20220317
IS  - 1472-6491 (Electronic)
IS  - 1472-6483 (Linking)
VI  - 18
IP  - 2
DP  - 2009 Feb
TI  - HMG improves IVF outcome in patients with high basal FSH/LH ratio: a preliminary 
      study.
PG  - 205-8
AB  - In an attempt to examine the role of human menopausal gonadotrophin (HMG) 
      administration in patients with high basal FSH/LH ratio, patients undergoing at 
      least two IVF cycles, where one included HMG (HMG group) and the other included 
      recombinant FSH (rFSH) only (FSH group), were studied. The use of HMG, in this 
      specific group of patients, produced significantly higher number of top-quality 
      embryos (3.9 +/- 3.1 versus 2.5 +/- 1.7, respectively; P < 0.05), higher 
      implantation (27.9% versus 5.3%, respectively; P +/- 0.003) and clinical 
      pregnancy rates (44.4% versus 11.1%, respectively; P < 0.02), as compared with 
      rFSH. Moreover, while the HMG group achieved a significantly higher peak 
      oestradiol concentration (P = 0.04), no differences were observed between the 
      groups in the other ovarian stimulation variables. In conclusion, the use of HMG 
      in patients with high basal FSH/LH ratio, produced significantly higher number of 
      top-quality embryos, and higher implantation and clinical pregnancy rates, 
      compared with rFSH.
FAU - Orvieto, Raoul
AU  - Orvieto R
AD  - Department of Obstetrics and Gynecology, Barzilai Medical Center, Ashkelon 78278, 
      Israel. raoulo@barzi.health.gov.il
FAU - Homburg, Roy
AU  - Homburg R
FAU - Meltcer, Simion
AU  - Meltcer S
FAU - Rabinson, Jacob
AU  - Rabinson J
FAU - Anteby, Eyal Y
AU  - Anteby EY
FAU - Nahum, Ravit
AU  - Nahum R
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (Recombinant Proteins)
RN  - 33515-09-2 (Gonadotropin-Releasing Hormone)
RN  - 61489-71-2 (Menotropins)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adult
MH  - Female
MH  - Fertilization in Vitro/*methods
MH  - Follicle Stimulating Hormone/*blood
MH  - Gonadotropin-Releasing Hormone/administration & dosage/agonists
MH  - Humans
MH  - Infertility/*therapy
MH  - Luteinizing Hormone/*blood
MH  - Menotropins/administration & dosage/*pharmacology
MH  - Pregnancy
MH  - Recombinant Proteins/administration & dosage/pharmacology
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2009/02/05 09:00
MHDA- 2009/05/02 09:00
CRDT- 2009/02/05 09:00
PHST- 2009/02/05 09:00 [entrez]
PHST- 2009/02/05 09:00 [pubmed]
PHST- 2009/05/02 09:00 [medline]
AID - S1472-6483(10)60257-X [pii]
AID - 10.1016/s1472-6483(10)60257-x [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2009 Feb;18(2):205-8. doi: 10.1016/s1472-6483(10)60257-x.