PMID- 19193231
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20211020
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 9
DP  - 2009 Feb 4
TI  - Family-based association study of the BDNF, COMT and serotonin transporter genes 
      and DSM-IV bipolar-I disorder in children.
PG  - 2
LID - 10.1186/1471-244X-9-2 [doi]
AB  - BACKGROUND: Over the past decade pediatric bipolar disorder has gained 
      recognition as a potentially more severe and heritable form of the disorder. In 
      this report we test for association with genes coding brain-derived neurotrophic 
      factor (BDNF), the serotonin transporter (SLC6A4), and 
      catechol-O-methyltransferase (COMT). METHODS: Bipolar-I affected offspring triads 
      (N = 173) were drawn from 522 individuals with 2 parents in 332 nuclear families 
      recruited for genetic studies of pediatric psychopathology at the Clinical and 
      Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts 
      General Hospital. RESULTS: We failed to identify an association with the val66 
      allele in BDNF (OR = 1.23, p = 0.36), the COMT-l allele (OR = 1.27, p = 0.1), or 
      the HTTLPR short allele (OR = 0.87, p = 0.38). CONCLUSION: Our study suggests 
      that the markers examined thus far in COMT and SLC6A4 are not associated with 
      pediatric bipolar disorder and that if the val66met marker in BDNF is associated 
      with pediatric bipolar disorder the magnitude of the association is much smaller 
      than first reported.
FAU - Mick, Eric
AU  - Mick E
AD  - Department of Psychiatry, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA, USA. mick@helix.mgh.harvard.edu
FAU - Wozniak, Janet
AU  - Wozniak J
FAU - Wilens, Timothy E
AU  - Wilens TE
FAU - Biederman, Joseph
AU  - Biederman J
FAU - Faraone, Stephen V
AU  - Faraone SV
LA  - eng
GR  - R01 MH066877/MH/NIMH NIH HHS/United States
GR  - R01HD37694/HD/NICHD NIH HHS/United States
GR  - R01MH050657/MH/NIMH NIH HHS/United States
GR  - K01MH065523/MH/NIMH NIH HHS/United States
GR  - R01 MH057934/MH/NIMH NIH HHS/United States
GR  - R01 MH066237/MH/NIMH NIH HHS/United States
GR  - R01 HD036317/HD/NICHD NIH HHS/United States
GR  - R01 HD037694/HD/NICHD NIH HHS/United States
GR  - R01MH066237/MH/NIMH NIH HHS/United States
GR  - K01 MH065523/MH/NIMH NIH HHS/United States
GR  - R01 DA012945/DA/NIDA NIH HHS/United States
GR  - R01HD036317/HD/NICHD NIH HHS/United States
GR  - R01MH57934/MH/NIMH NIH HHS/United States
GR  - R01MH066877/MH/NIMH NIH HHS/United States
GR  - K08MH001503/MH/NIMH NIH HHS/United States
GR  - R01DA012945/DA/NIDA NIH HHS/United States
GR  - R01 MH050657/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090204
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
RN  - EC 2.1.1.6 (Catechol O-Methyltransferase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Bipolar Disorder/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Catechol O-Methyltransferase/*genetics
MH  - Child
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Male
MH  - Nuclear Family
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
PMC - PMC2640390
EDAT- 2009/02/06 09:00
MHDA- 2009/04/03 09:00
PMCR- 2009/02/04
CRDT- 2009/02/06 09:00
PHST- 2008/09/22 00:00 [received]
PHST- 2009/02/04 00:00 [accepted]
PHST- 2009/02/06 09:00 [entrez]
PHST- 2009/02/06 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2009/02/04 00:00 [pmc-release]
AID - 1471-244X-9-2 [pii]
AID - 10.1186/1471-244X-9-2 [doi]
PST - epublish
SO  - BMC Psychiatry. 2009 Feb 4;9:2. doi: 10.1186/1471-244X-9-2.