PMID- 19193767
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20220309
IS  - 0022-3077 (Print)
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 101
IP  - 4
DP  - 2009 Apr
TI  - Timing-dependent regulation of evoked spiking in nucleus accumbens neurons by 
      integration of limbic and prefrontal cortical inputs.
PG  - 1823-35
LID - 10.1152/jn.91162.2008 [doi]
AB  - Single nucleus accumbens (NAcc) neurons receive excitatory synaptic input from 
      cortical and limbic structures, and the integration of converging goal- and 
      motivation-related signals in these neurons influences reward-directed actions. 
      While limbic/cortical synaptic input summation has been characterized at 
      subthreshold intensities, the manner in which multiple inputs govern NAcc neuron 
      spike discharge has not been measured and is poorly understood. Single NAcc 
      neurons were recorded in urethane-anesthetized rats, and spiking was evoked by 
      coincident stimulation of two major NAcc afferent regions: the basolateral 
      amygdala (BLA) and medial prefrontal cortex (mPFC). BLA input increased NAcc 
      spiking elicited by mPFC stimulation depending on the timing of the stimulation 
      pulses, consistent with the summation of monosynaptically evoked excitatory 
      activity. When mPFC input intensity was below threshold for evoked spiking, the 
      addition of BLA input produced the largest facilitation of evoked spiking, and 
      the latency of the evoked spikes reflected the latency of the individual inputs. 
      When mPFC inputs were stimulated at higher intensities, BLA-mediated facilitation 
      was weaker, and the spike latency reflected only the mPFC input. Thus NAcc 
      neurons integrate both the magnitude and timing of afferent synaptic activity, 
      suggesting that NAcc neuron output is strongly dependent on the comparative 
      magnitude of synaptic activity in its afferent structures. These interactions may 
      be crucial integrative mechanisms that allow motivational and cognitive 
      information to produce appropriate reward-directed actions.
FAU - McGinty, Vincent B
AU  - McGinty VB
AD  - Dept. of Neuroscience, A210 Langley Hall, University of Pittsburgh, Pittsburgh, 
      PA 15260. Graceaa@pitt.edu).
FAU - Grace, Anthony A
AU  - Grace AA
LA  - eng
GR  - R37 MH057440/MH/NIMH NIH HHS/United States
GR  - R37 MH057440-14/MH/NIMH NIH HHS/United States
GR  - MH-57440/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090204
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Benzazepines)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (SCH 23390)
RN  - 0 (Salicylamides)
RN  - 6LR8C1B66Q (Dizocilpine Maleate)
RN  - J8M468HBH4 (eticlopride)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Benzazepines/pharmacology
MH  - Biophysics
MH  - Brain Mapping
MH  - Dizocilpine Maleate/pharmacology
MH  - Dopamine Antagonists/pharmacology
MH  - Electric Stimulation/methods
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - Limbic System/*physiology
MH  - Male
MH  - Neural Pathways/physiology
MH  - Neurons/*physiology
MH  - Nucleus Accumbens/*cytology
MH  - Prefrontal Cortex/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reaction Time/*physiology
MH  - Salicylamides/pharmacology
PMC - PMC2695641
EDAT- 2009/02/06 09:00
MHDA- 2009/05/27 09:00
PMCR- 2010/04/01
CRDT- 2009/02/06 09:00
PHST- 2009/02/06 09:00 [entrez]
PHST- 2009/02/06 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 91162.2008 [pii]
AID - J91162-8 [pii]
AID - 10.1152/jn.91162.2008 [doi]
PST - ppublish
SO  - J Neurophysiol. 2009 Apr;101(4):1823-35. doi: 10.1152/jn.91162.2008. Epub 2009 
      Feb 4.