PMID- 19193769
OWN - NLM
STAT- MEDLINE
DCOM- 20090526
LR  - 20211020
IS  - 0022-3077 (Print)
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Linking)
VI  - 101
IP  - 4
DP  - 2009 Apr
TI  - Mental arithmetic leads to multiple discrete changes from baseline in the firing 
      patterns of human thalamic neurons.
PG  - 2107-19
LID - 10.1152/jn.91087.2008 [doi]
AB  - Primate thalamic action potential bursts associated with low-threshold spikes 
      (LTS) occur during waking sensory and motor activity. We now test the hypothesis 
      that different firing and LTS burst characteristics occur during quiet 
      wakefulness (spontaneous condition) versus mental arithmetic (counting 
      condition). This hypothesis was tested by thalamic recordings during the surgical 
      treatment of tremor. Across all neurons and epochs, preburst interspike intervals 
      (ISIs) were bimodal at median values, consistent with the duration of type A and 
      type B gamma-aminobutyric acid inhibitory postsynaptic potentials. Neuronal spike 
      trains (117 neurons) were categorized by joint ISI distributions into those 
      firing as LTS bursts (G, grouped), firing as single spikes (NG, nongrouped), or 
      firing as single spikes with sporadic LTS bursting (I, intermediate). During the 
      spontaneous condition (46 neurons) only I spike trains changed category. Overall, 
      burst rates (BRs) were lower and firing rates (FRs) were higher during the 
      counting versus the spontaneous condition. Spike trains in the G category 
      sometimes changed to I and NG categories at the transition from the spontaneous 
      to the counting condition, whereas those in the I category often changed to NG. 
      Among spike trains that did not change category by condition, G spike trains had 
      lower BRs during counting, whereas NG spike trains had higher FRs. BRs were 
      significantly greater than zero for G and I categories during wakefulness (both 
      conditions). The changes between the spontaneous and counting conditions are most 
      pronounced for the I category, which may be a transitional firing pattern between 
      the bursting (G) and relay modes of thalamic firing (NG).
FAU - Kim, J H
AU  - Kim JH
AD  - Department of Neurosurgery, Meyer Building 7-113, Johns Hopkins Hospital, 600 
      North Wolfe Street, Baltimore, MD 21287-7713, USA.
FAU - Ohara, S
AU  - Ohara S
FAU - Lenz, F A
AU  - Lenz FA
LA  - eng
GR  - NS-383493/NS/NINDS NIH HHS/United States
GR  - NS-40059/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090204
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Action Potentials/*physiology
MH  - Adult
MH  - Aged
MH  - Brain Mapping
MH  - Deep Brain Stimulation/methods
MH  - Essential Tremor/pathology/physiopathology/therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - *Mathematics
MH  - Mental Processes/*physiology
MH  - Middle Aged
MH  - Neurons/*physiology
MH  - Retrospective Studies
MH  - Thalamus/*pathology
MH  - Time Factors
PMC - PMC2695644
EDAT- 2009/02/06 09:00
MHDA- 2009/05/27 09:00
PMCR- 2010/04/01
CRDT- 2009/02/06 09:00
PHST- 2009/02/06 09:00 [entrez]
PHST- 2009/02/06 09:00 [pubmed]
PHST- 2009/05/27 09:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 91087.2008 [pii]
AID - J91087-8 [pii]
AID - 10.1152/jn.91087.2008 [doi]
PST - ppublish
SO  - J Neurophysiol. 2009 Apr;101(4):2107-19. doi: 10.1152/jn.91087.2008. Epub 2009 
      Feb 4.