PMID- 19195646
OWN - NLM
STAT- MEDLINE
DCOM- 20090820
LR  - 20220317
IS  - 1873-2402 (Electronic)
IS  - 0006-3223 (Linking)
VI  - 65
IP  - 12
DP  - 2009 Jun 15
TI  - Reward feedback alterations in unmedicated schizophrenia patients: relevance for 
      delusions.
PG  - 1032-9
LID - 10.1016/j.biopsych.2008.12.016 [doi]
AB  - BACKGROUND: Increased attribution of incentive salience to neutral or aversive 
      stimuli might be associated with dysfunction of neuronal processing of positive 
      and negative reinforcement and contribute to the formation of delusions in 
      schizophrenia. METHODS: Fifteen unmedicated patients with schizophrenia (8 
      drug-naive and 7 drug-free for at least 3 months) and 15 age- and gender-matched 
      healthy control participants underwent functional magnetic resonance imaging to 
      investigate neural responses to feedback of (successful vs. unsuccessful) 
      monetary gain or avoidance of loss. Functional connectivity was assessed between 
      the medial prefrontal cortex (MPFC) and ventral striatum (VS), brain areas known 
      to be activated by feedback of reward and loss. RESULTS: Responses to negative 
      outcome in reward trials (omission of expected reward) were exaggerated in the 
      MPFC of patients with schizophrenia. In contrast, schizophrenia patients showed 
      reduced neural responses to successful versus unsuccessful avoidance of loss in 
      the VS. Increased severity of delusions in schizophrenia patients was associated 
      with a decrease in MPFC activation elicited by successful versus unsuccessful 
      avoidance of loss. Functional connectivity between the MPFC and the VS was 
      reduced in patients with schizophrenia compared with healthy control subjects. 
      CONCLUSIONS: These findings demonstrate a differential impairment of-and reduced 
      connectivity between--VS and MPFC during processing of reward and loss-avoidance 
      in drug-free patients with schizophrenia. Moreover, our results provide a link 
      between the formation of delusions and the neural processing of aversive 
      outcomes.
FAU - Schlagenhauf, Florian
AU  - Schlagenhauf F
AD  - Department of Psychiatry and Psychotherapy, Charite - Universitatsmedizin Berlin, 
      Campus Mitte, Germany. florian.schlagenhauf@charite.de
FAU - Sterzer, Philipp
AU  - Sterzer P
FAU - Schmack, Katharina
AU  - Schmack K
FAU - Ballmaier, Martina
AU  - Ballmaier M
FAU - Rapp, Michael
AU  - Rapp M
FAU - Wrase, Jana
AU  - Wrase J
FAU - Juckel, Georg
AU  - Juckel G
FAU - Gallinat, Jurgen
AU  - Gallinat J
FAU - Heinz, Andreas
AU  - Heinz A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090205
PL  - United States
TA  - Biol Psychiatry
JT  - Biological psychiatry
JID - 0213264
SB  - IM
MH  - Adult
MH  - Delusions/*psychology
MH  - Feedback, Psychological/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Motivation
MH  - Neostriatum/physiology
MH  - Prefrontal Cortex/physiology
MH  - Reaction Time/physiology
MH  - *Reward
MH  - *Schizophrenic Psychology
MH  - Young Adult
EDAT- 2009/02/07 09:00
MHDA- 2009/08/21 09:00
CRDT- 2009/02/07 09:00
PHST- 2008/08/01 00:00 [received]
PHST- 2008/12/15 00:00 [revised]
PHST- 2008/12/15 00:00 [accepted]
PHST- 2009/02/07 09:00 [entrez]
PHST- 2009/02/07 09:00 [pubmed]
PHST- 2009/08/21 09:00 [medline]
AID - S0006-3223(08)01598-9 [pii]
AID - 10.1016/j.biopsych.2008.12.016 [doi]
PST - ppublish
SO  - Biol Psychiatry. 2009 Jun 15;65(12):1032-9. doi: 10.1016/j.biopsych.2008.12.016. 
      Epub 2009 Feb 5.