PMID- 19196011
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20220310
IS  - 1549-1684 (Print)
IS  - 1549-1684 (Linking)
VI  - 12
IP  - 1
DP  - 2009 Feb
TI  - Increased plasma neutrophil gelatinase-associated lipocalin levels predict 
      mortality in elderly patients with chronic heart failure.
PG  - 7-14
LID - 10.1089/rej.2008.0803 [doi]
AB  - Chronic congestive heart failure (CHF) is associated with an increase in 
      cytokines and inflammatory markers, particularly in elderly patients in whom 
      chronic inflammation is generally present per se. In the present pilot study, 
      neutrophil gelatinase-associated lipocalin (NGAL), a recently discovered 
      cytokine, was analyzed together with different clinical and laboratory parameters 
      in a small cohort of 46 elderly patients with CHF of various degrees. NGAL levels 
      in the cohort were found to be significantly higher than in healthy age-balanced 
      controls (458.5 [62.5-1212.4] vs. 37.8 [15.9-46.5] ng/mL; p = 0.0001). 
      Furthermore, NGAL values increased in parallel with the clinical severity of CHF 
      (New York Heart Association [NYHA] classification), the highest levels being 
      reached in class IV patients (p = 0.0001). After a 2-year follow up, Kaplan-Meier 
      curves indicated that patients with baseline NGAL > 783 ng/mL (best receiver 
      operating characteristic [ROC]-derived cut-off value) had a significantly higher 
      mortality (p = 0.001; log-rank test) and 4.08 hazards ratio (95% confidence 
      interval [CI], 1.29-12.96) for death than the other subjects considered. Although 
      preliminary, our findings suggest that NGAL plays a pivotal role in the systemic 
      adaptation to chronic heart failure in elderly patients. Moreover, they indicate, 
      for the first time, that measurement of NGAL may be of important prognostic value 
      in the assessment of survival, thus extending the predictive properties of this 
      cytokine beyond the clinical field of renal disease.
FAU - Bolignano, Davide
AU  - Bolignano D
AD  - Department of Nephrology, University of Messina, Messina, Italy.
FAU - Basile, Giorgio
AU  - Basile G
FAU - Parisi, Pina
AU  - Parisi P
FAU - Coppolino, Giuseppe
AU  - Coppolino G
FAU - Nicocia, Giacomo
AU  - Nicocia G
FAU - Buemi, Michele
AU  - Buemi M
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Rejuvenation Res
JT  - Rejuvenation research
JID - 101213381
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Acute-Phase Proteins
MH  - *Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - Cohort Studies
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/blood/*diagnosis/*mortality
MH  - Humans
MH  - Lipocalin-2
MH  - Lipocalins/*blood
MH  - Male
MH  - Pilot Projects
MH  - Prognosis
MH  - Proto-Oncogene Proteins/*blood
MH  - Sensitivity and Specificity
EDAT- 2009/02/07 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/02/07 09:00
PHST- 2009/02/07 09:00 [entrez]
PHST- 2009/02/07 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - 10.1089/rej.2008.0803 [pii]
AID - 10.1089/rej.2008.0803 [doi]
PST - ppublish
SO  - Rejuvenation Res. 2009 Feb;12(1):7-14. doi: 10.1089/rej.2008.0803.