PMID- 19196362
OWN - NLM
STAT- MEDLINE
DCOM- 20100118
LR  - 20100723
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 63
IP  - 2
DP  - 2009 Feb
TI  - Perceived medication adverse effects and coping strategies reported by chronic 
      heart failure patients.
PG  - 233-42
LID - 10.1111/j.1742-1241.2008.01954.x [doi]
AB  - BACKGROUND: Data on medication adverse effects (AEs) in chronic heart failure 
      (CHF) are primarily based on results from clinical trials. Little is known about 
      AEs perceived by CHF patients in daily practice and how patients deal with these 
      subjective AEs. AIMS: To describe the scope and nature of perceived AEs of CHF 
      patients, their coping strategies and the relationship of perceived AEs to 
      medication, patient characteristics and quality of life. METHODS: This 
      cross-sectional observational study included a sample of 680 patients previously 
      hospitalised for CHF. Perceived AEs and coping strategies were collected by 
      interviews based on a structured questionnaire. Medication and clinical 
      information were collected by chart review. RESULTS: Of the 670 CHF patients 
      completing the questionnaire, 17% reported at least one AE. In total, 186 AEs 
      were reported of which 15% could not be linked to any medication. Nausea (4%), 
      dizziness (4%), itches (3%) and rash (3%) were the most prevalent. The drug 
      associated with the highest AE rate was pravastatin (27%). On average, more than 
      five different drugs could be related to the AEs headache, dizziness and nausea. 
      Patients reporting AEs had a lower general health perception, younger age and 
      were more often using antiarrhythmic drugs. Of patients experiencing AEs, 69% 
      conferred with their doctor, 24% reported having done nothing in reaction and 2% 
      discontinued their medication without discussing it with the doctor. CONCLUSION: 
      Adverse effects are frequently perceived by CHF patients, but they are difficult 
      to recognise and manage in daily practice.
FAU - De Smedt, R H E
AU  - De Smedt RH
AD  - Department of Clinical Pharmacology, University Medical Center Groningen, 
      University of Groningen, The Netherlands. r.h.e.de.smedt@med.umcg.nl
FAU - Denig, P
AU  - Denig P
FAU - Haaijer-Ruskamp, F M
AU  - Haaijer-Ruskamp FM
FAU - Jaarsma, T
AU  - Jaarsma T
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Cardiovascular Agents)
RN  - 0 (Fibrinolytic Agents)
SB  - IM
EIN - Int J Clin Pract. 2009 May;63(5):829
MH  - *Adaptation, Psychological
MH  - Aged
MH  - Attitude to Health
MH  - Cardiovascular Agents/*adverse effects
MH  - Chronic Disease
MH  - Counseling
MH  - Female
MH  - Fibrinolytic Agents/adverse effects
MH  - Heart Failure/*drug therapy/psychology
MH  - Humans
MH  - Male
MH  - Patient Education as Topic
MH  - Perception
EDAT- 2009/02/07 09:00
MHDA- 2010/01/19 06:00
CRDT- 2009/02/07 09:00
PHST- 2009/02/07 09:00 [entrez]
PHST- 2009/02/07 09:00 [pubmed]
PHST- 2010/01/19 06:00 [medline]
AID - IJCP1954 [pii]
AID - 10.1111/j.1742-1241.2008.01954.x [doi]
PST - ppublish
SO  - Int J Clin Pract. 2009 Feb;63(2):233-42. doi: 10.1111/j.1742-1241.2008.01954.x.