PMID- 19196618
OWN - NLM
STAT- MEDLINE
DCOM- 20090331
LR  - 20180815
IS  - 1109-9666 (Print)
IS  - 1109-9666 (Linking)
VI  - 50
IP  - 1
DP  - 2009 Jan-Feb
TI  - The role of sex and biochemical markers of inflammation in left ventricular 
      remodelling, before and after surgery, in elderly patients with aortic valve 
      stenosis.
PG  - 26-36
AB  - INTRODUCTION: The aim of this study was to determine whether sex and biochemical 
      markers of inflammation have a role in left ventricular (LV) remodelling after 
      aortic valve replacement in elderly patients with aortic valve stenosis. METHODS: 
      We studied 52 elderly patients with aortic valve stenosis (32 men, mean age 65 
      +/- 11 years and 20 women, mean age 68 +/- 9 years). Body surface area did not 
      differ between men and women (1.81 +/- 0.15 versus 1.84 +/- 0.20, respectively). 
      All patients underwent a complete echocardiographic examination for the 
      determination of ejection fraction (EF), LV mass and mass index, peak and mean 
      systolic pressure gradient, aortic valve area, early (E) and late (A) transmitral 
      flow wave velocities and their ratio (E/A), tissue Doppler indexes of the mitral 
      annulus (Sa, Ea, Aa), and the E/Ea ratio. In addition, levels of high sensitivity 
      C-reactive protein (hsCRP), tumour necrosis factor-alpha (TNF-alpha) and monocyte 
      chemoattractant protein-1 (MCP-1) were measured from venous blood samples taken 
      before, and 10 days, 3 months and 6 months after aortic valve replacement. 
      RESULTS: LV mass decreased from 297 +/- 99.7 g before aortic valve replacement to 
      210 +/- 67 g 3 months after surgery and to 210 +/- 74 g 6 months after surgery 
      (p<0.001). LV EF did not change significantly (p=0.836). Peak and mean systolic 
      pressure gradients decreased, whereas aortic valve area increased after valve 
      replacement (p<0.001). These changes were similar in men and women. In women Sa 
      was greater (p=0.017) and the E/Ea ratio lower (p=0.025) than in men. The 
      long-term changes in peak and mean pressure gradients, aortic valve area and LV 
      mass after aortic valve replacement were well correlated with the long-term 
      changes in hsCRP, TNF-alpha and MCP-1 in both men and women. CONCLUSIONS: LV 
      remodelling is similar in elderly men and women with aortic valve disease who 
      have similar body surface area. Although inflammatory markers are not correlated 
      with echocardiographic parameters before aortic valve replacement, a strong 
      correlation exists after operation. This correlation is similar in men and women.
FAU - Kastellanos, Stylianos S
AU  - Kastellanos SS
AD  - Department of Cardiology, Preveza General Hospital, Athens, Greece. 
      castel@otenet.gr
FAU - Toumpoulis, Ioannis K
AU  - Toumpoulis IK
FAU - Aggeli, Constadina
AU  - Aggeli C
FAU - Zezas, Stefanos
AU  - Zezas S
FAU - Chlapoutakis, Emmanouil
AU  - Chlapoutakis E
FAU - Kastellanos, Stamatis
AU  - Kastellanos S
FAU - Stefanadis, Christodoulos I
AU  - Stefanadis CI
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Hellenic J Cardiol
JT  - Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
JID - 101257381
RN  - 0 (Biomarkers)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aortic Valve Stenosis/blood/*complications/*surgery
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sex Factors
MH  - Time Factors
MH  - Treatment Outcome
MH  - Tumor Necrosis Factor-alpha/*blood
MH  - Ventricular Remodeling/*physiology
EDAT- 2009/02/07 09:00
MHDA- 2009/04/01 09:00
CRDT- 2009/02/07 09:00
PHST- 2009/02/07 09:00 [entrez]
PHST- 2009/02/07 09:00 [pubmed]
PHST- 2009/04/01 09:00 [medline]
PST - ppublish
SO  - Hellenic J Cardiol. 2009 Jan-Feb;50(1):26-36.