PMID- 19198220
OWN - NLM
STAT- MEDLINE
DCOM- 20090326
LR  - 20211203
IS  - 0890-9091 (Print)
IS  - 0890-9091 (Linking)
VI  - 22
IP  - 14
DP  - 2008 Dec
TI  - Neuroendocrine tumors: novel approaches in the age of targeted therapy.
PG  - 1617-23; discussion 1623-4, 1629
AB  - The diagnosed incidence rate of neuroendocrine tumors (NETs) is on the rise. 
      Prevalence calculations show NETs to be more common then previously thought. 
      Although generally thought to be indolent, advanced NETs remain incurable and are 
      resistant to most cytotoxic agents. The available biologic agents have limited 
      activity against these tumors. Novel and active agents are clearly needed. The 
      recent emergence of molecularly targeted therapy in oncology has brought renewed 
      interest in the development of novel agents for this group of diseases. This 
      paper will review the molecular biology of NETs, promising novel targeted therapy 
      approaches including agents targeting angiogenesis and mammalian target of 
      rapamycin (mTOR) pathways, as well as pivotal phase III studies that may set new 
      standards of care for this disease.
FAU - Phan, Alexandria T
AU  - Phan AT
AD  - Gastrointestinal Medical Oncology, The University of Texas M.D. Anderson Cancer 
      Center, Houston, Texas 77030, USA.
FAU - Yao, James C
AU  - Yao JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Oncology (Williston Park)
JT  - Oncology (Williston Park, N.Y.)
JID - 8712059
RN  - 0 (Antineoplastic Agents)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Clinical Trials, Phase II as Topic
MH  - Clinical Trials, Phase III as Topic
MH  - *Drug Design
MH  - Humans
MH  - Neovascularization, Pathologic/*drug therapy
MH  - Neuroendocrine Tumors/*drug therapy
MH  - Protein Kinases
MH  - TOR Serine-Threonine Kinases
EDAT- 2009/02/10 09:00
MHDA- 2009/03/27 09:00
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/03/27 09:00 [medline]
PST - ppublish
SO  - Oncology (Williston Park). 2008 Dec;22(14):1617-23; discussion 1623-4, 1629.