PMID- 19199252
OWN - NLM
STAT- MEDLINE
DCOM- 20090520
LR  - 20091119
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 26
IP  - 1
DP  - 2009 Feb
TI  - [Sperm-fluorescence in situ hybridization analysis in patients with pericentric 
      inversions of Y chromosome].
PG  - 54-6
LID - 10.3760/cma.j.issn.1003-9406.2009.01.012 [doi]
AB  - OBJECTIVE: To analyze the sex chromosome meiotic segregation in inv(Y) patients 
      by fluorescence in situ hybridization (FISH). METHODS: Conventional cytogenetic 
      procedures (GTG and CBG banding) and FISH were performed on metaphase chromosome. 
      Three-color FISH was performed on sperm samples using a probe mixture containing 
      CEPX, Tel Xp/Yp and Tel Xq/Yq to investigate the sex chromosome segregation of 
      five inv(Y) (p11.1q11.2) carriers. A healthy man with normal semen parameters was 
      used as control. RESULTS: There was no statistical difference in the abnormal sex 
      chromosome number and recombination frequencies in each spermatozoon from the 
      patient in comparison with that in the control. CONCLUSION: There was no apparent 
      sex chromosome abnormality in the sperm of the inv(Y) (p11.1q11.2) carriers. 
      Sperm-FISH allows further understanding of the sex chromosome segregation pattern 
      and an accurate genetic counseling.
FAU - Luo, Yu-qin
AU  - Luo YQ
AD  - Department of Clinical Laboratory, Women's Hospital, Zhejiang University School 
      of Medicine, Hangzhou, Zhejiang, 310006 PR China.
FAU - Qian, Yu-li
AU  - Qian YL
FAU - Lu, Huan-ming
AU  - Lu HM
FAU - Xu, Chen-ming
AU  - Xu CM
FAU - Jin, Fan
AU  - Jin F
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Case-Control Studies
MH  - *Chromosome Inversion
MH  - Chromosomes, Human, Y/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Male
MH  - Meiosis/genetics
MH  - Recombination, Genetic
MH  - Sex Chromosome Aberrations
MH  - Spermatozoa/*metabolism/pathology
EDAT- 2009/02/10 09:00
MHDA- 2009/05/21 09:00
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/05/21 09:00 [medline]
AID - 940626012 [pii]
AID - 10.3760/cma.j.issn.1003-9406.2009.01.012 [doi]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009 Feb;26(1):54-6. doi: 
      10.3760/cma.j.issn.1003-9406.2009.01.012.