PMID- 19200078
OWN - NLM
STAT- MEDLINE
DCOM- 20090713
LR  - 20131121
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 29
IP  - 4
DP  - 2009 Feb
TI  - Integration and sensory experience-dependent survival of newly-generated neurons 
      in the accessory olfactory bulb of female mice.
PG  - 679-92
LID - 10.1111/j.1460-9568.2009.06614.x [doi]
AB  - Newborn neurons generated by proliferative progenitors in the adult 
      subventricular zone (SVZ) integrate into the olfactory bulb circuitry of mammals. 
      Survival of these newly-formed cells is regulated by the olfactory input. The 
      presence of new neurons in the accessory olfactory bulb (AOB) has already been 
      demonstrated in some mammalian species, albeit their neurochemical profile and 
      functional integration into AOB circuits are still to be investigated. To unravel 
      whether the mouse AOB represents a site of adult constitutive neurogenesis and 
      whether this process can be modulated by extrinsic factors, we have used multiple 
      in vivo approaches. These included fate mapping of bromodeoxyuridine-labelled 
      cells, lineage tracing of SVZ-derived enhanced green fluorescent protein-positive 
      engrafted cells and neurogenesis quantification in the AOB, in both sexes, as 
      well as in females alone after exposure to male-soiled bedding or its derived 
      volatiles. Here, we show that a subpopulation of SVZ-derived neuroblasts acquires 
      proper neurochemical profiles of mature AOB interneurons. Moreover, 3D 
      reconstruction of long-term survived engrafted neuroblasts in the AOB confirms 
      these cells show features of fully integrated neurons. Finally, exposure to 
      male-soiled bedding, but not to its volatile compounds, significantly increases 
      the number of new neurons in the AOB, but not in the main olfactory bulb of 
      female mice. These data show SVZ-derived neuroblasts differentiate into new 
      functionally integrated neurons in the AOB of young and adult mice. Survival of 
      these cells seems to be regulated by an experience-specific mechanism mediated by 
      pheromones.
FAU - Oboti, L
AU  - Oboti L
AD  - Department of Animal and Human Biology, Via Accademia Albertina 13, Turin, Italy.
FAU - Savalli, G
AU  - Savalli G
FAU - Giachino, C
AU  - Giachino C
FAU - De Marchis, S
AU  - De Marchis S
FAU - Panzica, G C
AU  - Panzica GC
FAU - Fasolo, A
AU  - Fasolo A
FAU - Peretto, P
AU  - Peretto P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090206
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Pheromones)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - G34N38R2N1 (Bromodeoxyuridine)
SB  - IM
MH  - Animals
MH  - Bromodeoxyuridine
MH  - Cell Survival
MH  - Cerebral Ventricles/physiology
MH  - Female
MH  - Imaging, Three-Dimensional
MH  - Male
MH  - Mice
MH  - Neurogenesis
MH  - Neurons/cytology/*physiology
MH  - Olfactory Bulb/anatomy & histology/*physiology
MH  - Organ Size
MH  - Pheromones
MH  - Physical Stimulation
MH  - Prosencephalon/cytology/physiology
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Sex Characteristics
MH  - Smell/*physiology
MH  - Time
EDAT- 2009/02/10 09:00
MHDA- 2009/07/14 09:00
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/07/14 09:00 [medline]
AID - EJN6614 [pii]
AID - 10.1111/j.1460-9568.2009.06614.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2009 Feb;29(4):679-92. doi: 10.1111/j.1460-9568.2009.06614.x. 
      Epub 2009 Feb 6.