PMID- 19200827
OWN - NLM
STAT- MEDLINE
DCOM- 20090722
LR  - 20240419
IS  - 0264-410X (Print)
IS  - 1873-2518 (Electronic)
IS  - 0264-410X (Linking)
VI  - 27
IP  - 25-26
DP  - 2009 May 26
TI  - Gender effects on humoral immune responses to smallpox vaccine.
PG  - 3319-23
LID - 10.1016/j.vaccine.2009.01.086 [doi]
AB  - There are no data currently available on gender and racial variation in smallpox 
      vaccine immune responses. We recruited 1076 healthy adults 18-40 years old who 
      received one dose of the US-licensed smallpox vaccine (Dryvax). Vaccinia 
      neutralizing antibody titers in each subject's serum were determined using a high 
      throughput neutralization assay based on a recombinant, beta-gal expressing 
      vaccinia virus. Results are reported as the serum dilution inhibiting 50% of 
      virus activity (ID(50)). The median ID(50) for all subjects was 132.2 
      (inter-quartile range (IQR)=78.8, 205.6). While no significant differences were 
      observed with race and ethnicity, females had significantly higher neutralizing 
      antibody titers than males (158.5 [93.2, 255.8] vs. 124.1 [75.2, 185.9]; 
      p<0.0001). As expected, time since vaccination was also associated with 
      variations in neutralizing antibody titers in our subjects. These data indicate 
      that neutralizing antibody titers following primary smallpox vaccination vary by 
      gender.
FAU - Kennedy, Richard B
AU  - Kennedy RB
AD  - Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN, USA.
FAU - Ovsyannikova, Inna G
AU  - Ovsyannikova IG
FAU - Pankratz, V Shane
AU  - Pankratz VS
FAU - Vierkant, Robert A
AU  - Vierkant RA
FAU - Jacobson, Robert M
AU  - Jacobson RM
FAU - Ryan, Margaret A K
AU  - Ryan MA
FAU - Poland, Gregory A
AU  - Poland GA
LA  - eng
GR  - 1 UL1 RR024150-01/RR/NCRR NIH HHS/United States
GR  - N01 AI040065/AI/NIAID NIH HHS/United States
GR  - N01AI40065/AI/NIAID NIH HHS/United States
GR  - UL1 RR024150/RR/NCRR NIH HHS/United States
GR  - UL1 RR024150-01/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090205
PL  - Netherlands
TA  - Vaccine
JT  - Vaccine
JID - 8406899
RN  - 0 (Antibodies, Viral)
RN  - 0 (Smallpox Vaccine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Neutralization Tests
MH  - Sex Characteristics
MH  - Smallpox Vaccine/*immunology
MH  - Vaccination
PMC - PMC2831636
MID - NIHMS179500
EDAT- 2009/02/10 09:00
MHDA- 2009/07/23 09:00
PMCR- 2010/05/26
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/07/23 09:00 [medline]
PHST- 2010/05/26 00:00 [pmc-release]
AID - S0264-410X(09)00096-6 [pii]
AID - 10.1016/j.vaccine.2009.01.086 [doi]
PST - ppublish
SO  - Vaccine. 2009 May 26;27(25-26):3319-23. doi: 10.1016/j.vaccine.2009.01.086. Epub 
      2009 Feb 5.