PMID- 19201217
OWN - NLM
STAT- MEDLINE
DCOM- 20090803
LR  - 20231213
IS  - 1528-395X (Electronic)
IS  - 1079-2104 (Linking)
VI  - 107
IP  - 5
DP  - 2009 May
TI  - Mature dendritic cells in inflamed human pulps beneath deep caries.
PG  - 727-32
LID - 10.1016/j.tripleo.2008.11.020 [doi]
AB  - OBJECTIVE: Dendritic cells (DCs) in pulps have been identified with markers for 
      immature DCs and the relationship of DC maturity to pulpal health has not been 
      carefully examined. We sought to test the hypothesis that the frequency of CD83+ 
      mature DCs would correlate with caries invasion. STUDY DESIGN: Pulps were 
      collected from extracted teeth exhibiting (I) no caries (n = 9), (II) shallow 
      dentinal caries (n = 5), and (III) deep caries (n = 9). Immature DCs (CD209+), 
      mature DCs (CD83+), and monocytes/macrophages (CD14+) in three groups were 
      enumerated immunohistochemically. RESULTS: Mature DCs were frequently found 
      beneath deep caries (21.3 mature DCs/3 grids versus <1 in groups I and II) with 
      increasing numbers of CD209+ DCs and CD14+ cells. Co-localization of CD4+ T cells 
      with mature DCs and macrophages was observed in deep caries. CONCLUSION: Mature 
      DCs were frequently found only beneath deep caries and these DCs were 
      co-localized with CD4+ T cells suggesting antigen presentation.
FAU - Harmon, Melissa A
AU  - Harmon MA
AD  - Department of Endodontics, School of Dentistry, Virginia Commonwealth University, 
      Richmond, VA, USA.
FAU - Tew, John G
AU  - Tew JG
FAU - Best, Al M
AU  - Best AM
FAU - Hahn, Chin-Lo
AU  - Hahn CL
LA  - eng
PT  - Journal Article
DEP - 20090206
PL  - United States
TA  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod
JT  - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
JID - 9508562
RN  - 0 (Antigens, CD)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Immunoglobulins)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Antigen Presentation
MH  - Antigens, CD/analysis
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - Cell Adhesion Molecules/analysis
MH  - Cell Count
MH  - Dendritic Cells/*immunology/pathology
MH  - Dental Caries/complications/*immunology/pathology
MH  - Humans
MH  - Immunoglobulins/analysis
MH  - Immunohistochemistry/methods
MH  - Lectins, C-Type/analysis
MH  - Lipopolysaccharide Receptors/analysis
MH  - Macrophages/immunology
MH  - Membrane Glycoproteins/analysis
MH  - Monocytes/immunology
MH  - Pulpitis/etiology/*immunology/pathology
MH  - Receptors, Cell Surface/analysis
MH  - CD83 Antigen
EDAT- 2009/02/10 09:00
MHDA- 2009/08/04 09:00
CRDT- 2009/02/10 09:00
PHST- 2008/09/22 00:00 [received]
PHST- 2008/11/11 00:00 [revised]
PHST- 2008/11/18 00:00 [accepted]
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/08/04 09:00 [medline]
AID - S1079-2104(08)00875-5 [pii]
AID - 10.1016/j.tripleo.2008.11.020 [doi]
PST - ppublish
SO  - Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 May;107(5):727-32. doi: 
      10.1016/j.tripleo.2008.11.020. Epub 2009 Feb 6.