PMID- 19201746
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20171116
IS  - 1550-8080 (Electronic)
IS  - 0091-7370 (Linking)
VI  - 39
IP  - 1
DP  - 2009 Winter
TI  - Ketogenic diet reduces cytochrome c release and cellular apoptosis following 
      traumatic brain injury in juvenile rats.
PG  - 76-83
AB  - Ketone bodies have been shown to be favorable alternative metabolic substrates 
      and are protective under neuropathologies. At the same time, cytochrome c release 
      has been reported following traumatic brain injury (TBI) and precipitates 
      apoptosis via the mitochondrial pathway. The present study investigated the 
      effects of a ketogenic diet (KD) on TBI. TBI was produced using the Feeney 
      weight-drop model and the animals were fed either normal diet (ND) or KD. Brain 
      edema was estimated by wet/dry weight ratio; cytochrome c was detected by Western 
      blotting; cellular apoptosis in the penumbra area was examined by terminal 
      deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and active 
      caspase-3 immunohistochemical staining. The results show that brain edema, 
      cytochrome c release, and cellular apoptosis were induced after TBI and that KD 
      reduced these changes dramatically. These findings suggest that KD has potential 
      therapeutic benefit in TBI.
FAU - Hu, Zhi Gang
AU  - Hu ZG
AD  - Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing 
      University, Nanjing, Jiangsu, China.
FAU - Wang, Han Dong
AU  - Wang HD
FAU - Jin, Wei
AU  - Jin W
FAU - Yin, Hong Xia
AU  - Yin HX
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Clin Lab Sci
JT  - Annals of clinical and laboratory science
JID - 0410247
RN  - 0 (Blood Glucose)
RN  - 059QF0KO0R (Water)
RN  - 9007-43-6 (Cytochromes c)
RN  - EC 3.4.22.- (Caspase 3)
RN  - TZP1275679 (3-Hydroxybutyric Acid)
SB  - IM
MH  - 3-Hydroxybutyric Acid/blood
MH  - Animals
MH  - *Apoptosis
MH  - Blood Glucose
MH  - Brain/enzymology/pathology
MH  - Brain Injuries/blood/enzymology/*metabolism/*pathology
MH  - Caspase 3/metabolism
MH  - Cytochromes c/*metabolism
MH  - *Diet, Ketogenic
MH  - Enzyme Activation
MH  - Immunoblotting
MH  - In Situ Nick-End Labeling
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Water/metabolism
EDAT- 2009/02/10 09:00
MHDA- 2009/03/26 09:00
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
AID - 39/1/76 [pii]
PST - ppublish
SO  - Ann Clin Lab Sci. 2009 Winter;39(1):76-83.