PMID- 19202072
OWN - NLM
STAT- MEDLINE
DCOM- 20090406
LR  - 20211020
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 106
IP  - 8
DP  - 2009 Feb 24
TI  - Methylphenidate-induced dendritic spine formation and DeltaFosB expression in 
      nucleus accumbens.
PG  - 2915-20
LID - 10.1073/pnas.0813179106 [doi]
AB  - Methylphenidate is the psychostimulant medication most commonly prescribed to 
      treat attention deficit hyperactivity disorder (ADHD). Recent trends in the high 
      usage of methylphenidate for both therapeutic and nontherapeutic purposes 
      prompted us to investigate the long-term effects of exposure to the drug on 
      neuronal adaptation. We compared the effects of chronic methylphenidate or 
      cocaine (15 mg/kg, 14 days for both) exposure in mice on dendritic spine 
      morphology and DeltaFosB expression in medium-sized spiny neurons (MSN) from 
      ventral and dorsal striatum. Chronic methylphenidate increased the density of 
      dendritic spines in MSN-D1 (MSN-expressing dopamine D1 receptors) from the core 
      and shell of nucleus accumbens (NAcc) as well as MSN-D2 (MSN-expressing dopamine 
      D2 receptors) from the shell of NAcc. In contrast, cocaine increased the density 
      of spines in both populations of MSN from all regions of striatum. In general, 
      the effect of methylphenidate on the increase of shorter spines (class 2) was 
      less than that of cocaine. Interestingly, the methylphenidate-induced increase in 
      the density of relatively longer spines (class 3) in the shell of NAcc was bigger 
      than that induced by cocaine. Furthermore, methylphenidate exposure increased 
      expression of DeltaFosB only in MSN-D1 from all areas of striatum, and 
      surprisingly, the increase was greater than that induced by cocaine. Thus, our 
      results show differential effects of methylphenidate and cocaine on neuronal 
      adaptation in specific types of MSN in reward-related brain regions.
FAU - Kim, Yong
AU  - Kim Y
AD  - Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, 
      1230 York Avenue, New York, NY 10065, USA.
FAU - Teylan, Merilee A
AU  - Teylan MA
FAU - Baron, Matthew
AU  - Baron M
FAU - Sands, Adam
AU  - Sands A
FAU - Nairn, Angus C
AU  - Nairn AC
FAU - Greengard, Paul
AU  - Greengard P
LA  - eng
GR  - P01 DA010044/DA/NIDA NIH HHS/United States
GR  - DA10044/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20090206
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Fosb protein, mouse)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 207ZZ9QZ49 (Methylphenidate)
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - Cocaine/pharmacology
MH  - Dendritic Spines/*drug effects
MH  - Fluorescent Dyes/administration & dosage
MH  - Immunohistochemistry
MH  - Methylphenidate/*pharmacology
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Fluorescence
MH  - Nucleus Accumbens/*drug effects/metabolism
MH  - Proto-Oncogene Proteins c-fos/*metabolism
PMC - PMC2650365
COIS- The authors declare no conflict of interest.
EDAT- 2009/02/10 09:00
MHDA- 2009/04/07 09:00
PMCR- 2009/08/24
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/04/07 09:00 [medline]
PHST- 2009/08/24 00:00 [pmc-release]
AID - 0813179106 [pii]
AID - 6720 [pii]
AID - 10.1073/pnas.0813179106 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2915-20. doi: 
      10.1073/pnas.0813179106. Epub 2009 Feb 6.