PMID- 19202515
OWN - NLM
STAT- MEDLINE
DCOM- 20090731
LR  - 20151119
IS  - 0026-4725 (Print)
IS  - 0026-4725 (Linking)
VI  - 57
IP  - 1
DP  - 2009 Feb
TI  - Clinical significance of macrophage colony stimulating factor levels in acute 
      coronary syndrome.
PG  - 7-11
AB  - AIM: The aim of this paper was to ascertain whether macrophage colony stimulating 
      factor (MCSF) serum levels, measured during the acute phase of coronary syndromes 
      (ACS), are useful to predict short term outcomes. METHODS: Seventy-four 
      consecutive patients (mean age: 66+/-12), admitted to the Intensive Coronary Care 
      Unit of Palermo University Hospital (Italy) affected by ACS were observed; 39 
      patients showed a non ST elevation (NSTEMI) and 35 showed a ST elevation 
      myocardial infarction (STEMI). During the hospital stay, all patients underwent 
      echocardiography and 84% of patients received coronary angiography. Peripheral 
      venous blood samples were collected for the determination of serum levels of 
      MCSF, C-reactive protein (CRP), fibrinogen, I troponin and complete lipid 
      pattern. RESULTS: There was no significant difference in MCSF concentrations for 
      STEMI versus NSTEMI patients (326.65+/-143.87 vs 297.15+/-110.43 pg/mL, P=NS). 
      Higher levels of MCSF (363.00+/-147.61 vs 251.00+/-186.69, P=0.03) and CRP 
      (1.04+/-0.40 vs 0.97+/-0.50 mg/L, P=0.03) were found in patients with a worst in 
      hospital stay (recurrence of angina, re-infarction, death) and with a more severe 
      coronary artery disease (330.03+/-241.51 vs 223.61+/-128.29 pg/mL, P=0.04 and 
      1.14+/-0.50 vs 0.60+/-0.22 mg/L, P=0.05). CONCLUSIONS: MCSF levels are useful in 
      the prediction of short term prognosis in ACS patients.
FAU - Novo, G
AU  - Novo G
AD  - Division of Cardiology, Department of Internal Medicine, University of Palermo, 
      Palermo, Italy. novog@unipa.it
FAU - Assennato, P
AU  - Assennato P
FAU - Caruso, M
AU  - Caruso M
FAU - Turturici, C
AU  - Turturici C
FAU - Balistreri, C R
AU  - Balistreri CR
FAU - Amoroso, G R
AU  - Amoroso GR
FAU - Fazio, G
AU  - Fazio G
FAU - Rotolo, A
AU  - Rotolo A
FAU - Coppola, G
AU  - Coppola G
FAU - Hoffmann, E
AU  - Hoffmann E
FAU - Caruso, C
AU  - Caruso C
FAU - Novo, S
AU  - Novo S
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Minerva Cardioangiol
JT  - Minerva cardioangiologica
JID - 0400725
RN  - 0 (Biomarkers)
RN  - 0 (Lipids)
RN  - 0 (Troponin I)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
RN  - 9001-32-5 (Fibrinogen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Coronary Syndrome/*blood/diagnosis
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - C-Reactive Protein/*metabolism
MH  - Electrocardiography
MH  - Emergency Treatment
MH  - Female
MH  - Fibrinogen/metabolism
MH  - Humans
MH  - Lipids/blood
MH  - Macrophage Colony-Stimulating Factor/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood/diagnosis
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Troponin I/blood
EDAT- 2009/02/10 09:00
MHDA- 2009/08/01 09:00
CRDT- 2009/02/10 09:00
PHST- 2009/02/10 09:00 [entrez]
PHST- 2009/02/10 09:00 [pubmed]
PHST- 2009/08/01 09:00 [medline]
PST - ppublish
SO  - Minerva Cardioangiol. 2009 Feb;57(1):7-11.