PMID- 19203227
OWN - NLM
STAT- MEDLINE
DCOM- 20100922
LR  - 20140408
IS  - 1557-9042 (Electronic)
IS  - 0897-7151 (Linking)
VI  - 26
IP  - 8
DP  - 2009 Aug
TI  - Conditional knockout of brain-derived neurotrophic factor in the hippocampus 
      increases death of adult-born immature neurons following traumatic brain injury.
PG  - 1325-35
AB  - It has been reported that the hippocampus is particularly vulnerable to traumatic 
      brain injury (TBI), the consequence of which results in hippocampal-dependent 
      cognitive impairment. In the previous study we found that adult-born immature 
      neurons in the hippocampal dentate gyrus are the most vulnerable cell type to 
      moderate TBI insult. However, the molecular mechanisms that regulate the survival 
      of adult-born immature neurons in the hippocampus following TBI are still not 
      well understood. Here, we conditionally knocked out brain-derived neurotrophic 
      factor (BDNF) in the hippocampal dentate gyrus and examined the death of 
      adult-born immature neurons following moderate TBI. The results showed that the 
      amount of adult-born immature neuron death in the hippocampal dentate gyrus 
      significantly increased in the BDNF conditional knockout mice. This result 
      suggests that BDNF is involved in regulating the survival of adult-born immature 
      neurons in the hippocampus following TBI, and potentially might be a useful 
      target for preventing the adult-born immature neurons from death following TBI.
FAU - Gao, Xiang
AU  - Gao X
AD  - Spinal Cord and Brain Injury Research Group, Indiana University, Indianapolis, IN 
      46202, USA.
FAU - Chen, Jinhui
AU  - Chen J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurotrauma
JT  - Journal of neurotrauma
JID - 8811626
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Brain Injuries/genetics/metabolism/*pathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Cell Death/*genetics
MH  - Hippocampus/metabolism/*pathology
MH  - Immunohistochemistry
MH  - Mice
MH  - Mice, Knockout
MH  - Neurogenesis/*physiology
MH  - Neurons/metabolism/*pathology
EDAT- 2009/02/11 09:00
MHDA- 2010/09/24 06:00
CRDT- 2009/02/11 09:00
PHST- 2009/02/11 09:00 [entrez]
PHST- 2009/02/11 09:00 [pubmed]
PHST- 2010/09/24 06:00 [medline]
AID - 10.1089/neu.2008-0744 [pii]
AID - 10.1089/neu.2008.0744 [doi]
PST - ppublish
SO  - J Neurotrauma. 2009 Aug;26(8):1325-35. doi: 10.1089/neu.2008.0744.