PMID- 19203589
OWN - NLM
STAT- MEDLINE
DCOM- 20090804
LR  - 20211020
IS  - 0165-0173 (Print)
IS  - 0165-0173 (Linking)
VI  - 60
IP  - 1
DP  - 2009 Apr
TI  - Roles of transient receptor potential channels in pain.
PG  - 2-23
LID - 10.1016/j.brainresrev.2008.12.018 [doi]
AB  - Pain perception begins with the activation of primary sensory nociceptors. Over 
      the past decade, flourishing research has revealed that members of the Transient 
      Receptor Potential (TRP) ion channel family are fundamental molecules that detect 
      noxious stimuli and transduce a diverse range of physical and chemical energy 
      into action potentials in somatosensory nociceptors. Here we highlight the roles 
      of TRP vanilloid 1 (TRPV1), TRP melastatin 8 (TRPM8) and TRP ankyrin 1 (TRPA1) in 
      the activation of nociceptors by heat and cold environmental stimuli, mechanical 
      force, and by chemicals including exogenous plant and environmental compounds as 
      well as endogenous inflammatory molecules. The contribution of these channels to 
      pain and somatosensation is discussed at levels ranging from whole animal 
      behavior to molecular modulation by intracellular signaling proteins. An emerging 
      theme is that TRP channels are not simple ion channel transducers of one or two 
      stimuli, but instead serve multidimensional roles in signaling sensory stimuli 
      that are exceptionally diverse in modality and in their environmental milieu.
FAU - Stucky, Cheryl L
AU  - Stucky CL
AD  - Department of Cell Biology, Neurobiology and Anatomy, Medical College of 
      Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. cstucky@mcw.edu
FAU - Dubin, Adrienne E
AU  - Dubin AE
FAU - Jeske, Nathaniel A
AU  - Jeske NA
FAU - Malin, Sacha A
AU  - Malin SA
FAU - McKemy, David D
AU  - McKemy DD
FAU - Story, Gina M
AU  - Story GM
LA  - eng
GR  - NS061884/NS/NINDS NIH HHS/United States
GR  - NS40538/NS/NINDS NIH HHS/United States
GR  - NS050758/NS/NINDS NIH HHS/United States
GR  - R01 NS054069/NS/NINDS NIH HHS/United States
GR  - NIDDK063922/PHS HHS/United States
GR  - R01 NS061884-01A1/NS/NINDS NIH HHS/United States
GR  - R01 NS040538/NS/NINDS NIH HHS/United States
GR  - R01 NS050758/NS/NINDS NIH HHS/United States
GR  - R01 NS031826/NS/NINDS NIH HHS/United States
GR  - R01 NS040538-08/NS/NINDS NIH HHS/United States
GR  - NS054069/NS/NINDS NIH HHS/United States
GR  - R01 NS054069-04/NS/NINDS NIH HHS/United States
GR  - NS31826/NS/NINDS NIH HHS/United States
GR  - R01 NS061884/NS/NINDS NIH HHS/United States
GR  - R01 NS040538-07/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20081231
PL  - Netherlands
TA  - Brain Res Rev
JT  - Brain research reviews
JID - 101300366
RN  - 0 (Ank1 protein, mouse)
RN  - 0 (Ankyrins)
RN  - 0 (TRPM Cation Channels)
RN  - 0 (TRPV Cation Channels)
RN  - 0 (TRPV1 protein, mouse)
RN  - 0 (Transient Receptor Potential Channels)
RN  - 0 (Trpm1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Ankyrins/physiology
MH  - Humans
MH  - Nervous System/metabolism/*physiopathology
MH  - Nociceptors/*physiology
MH  - Pain/metabolism/*physiopathology
MH  - Sensation/physiology
MH  - Sensory Receptor Cells/*physiology
MH  - Signal Transduction/*physiology
MH  - TRPM Cation Channels/physiology
MH  - TRPV Cation Channels/physiology
MH  - Transient Receptor Potential Channels/*physiology
PMC - PMC2683630
MID - NIHMS107231
EDAT- 2009/02/11 09:00
MHDA- 2009/08/06 09:00
PMCR- 2009/05/18
CRDT- 2009/02/11 09:00
PHST- 2008/12/29 00:00 [accepted]
PHST- 2009/02/11 09:00 [entrez]
PHST- 2009/02/11 09:00 [pubmed]
PHST- 2009/08/06 09:00 [medline]
PHST- 2009/05/18 00:00 [pmc-release]
AID - S0165-0173(08)00157-4 [pii]
AID - 10.1016/j.brainresrev.2008.12.018 [doi]
PST - ppublish
SO  - Brain Res Rev. 2009 Apr;60(1):2-23. doi: 10.1016/j.brainresrev.2008.12.018. Epub 
      2008 Dec 31.