PMID- 19204431
OWN - NLM
STAT- MEDLINE
DCOM- 20090508
LR  - 20171116
IS  - 1423-0151 (Electronic)
IS  - 1011-7571 (Linking)
VI  - 18
IP  - 2
DP  - 2009
TI  - Which obesity index best explains the link between adipokines, coronary heart 
      disease risk and metabolic abnormalities in type 2 diabetes mellitus?
PG  - 123-9
LID - 10.1159/000189810 [doi]
AB  - OBJECTIVE: The aim of this study was to determine, which of: body mass index 
      (BMI), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR) and waist 
      circumference (WC) correlates best with adipokines and is, therefore, the most 
      suitable for the assessment of insulin resistance (IR), metabolic syndrome (MS), 
      type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD) risk. SUBJECTS 
      AND METHODS: We studied 248 T2DM patients classified by gender, IR, MS and CHD. 
      Fasting adiponectin, leptin, resistin, high-sensitivity C-reactive protein (CRP), 
      insulin, glucose, IR (HOMA), and lipid profile were measured. Univariate and 
      multivariate regression analyses were used to find the associations of these 
      variables with each other and with IR, MS and CHD. Receiver operating 
      characteristic (ROC) analyses were used to find the best markers of IR, MS and 
      CHD. RESULTS: There were gender differences in the correlations and associations 
      of BMI, WHR, WHtR and WC with IR, MS and CHD; e.g. in males, WHR showed 
      significant correlation with only resistin (r = 0.30) and leptin (r = 0.39) 
      whereas in females, it showed significant correlations with only adiponectin (r = 
      -0.33). In males and females WHR showed the weakest correlations with CRP and the 
      adipokines and BMI showed the highest correlations. ROC analysis showed that the 
      BMI had the highest diagnostic values for detection of IR, MS and CHD; WHR had 
      the worst diagnostic value. CONCLUSION: Anthropometric indices show differences 
      in performance and associations with adipokines, CRP, IR, MS and CHD. In patients 
      with T2DM, BMI should be the preferred marker for risk assessment on account of 
      its association with adipokines and diagnostic performance characteristics.
CI  - Copyright 2009 S. Karger AG, Basel.
FAU - Mojiminiyi, Olusegun A
AU  - Mojiminiyi OA
AD  - Department of Pathology, Faculty of Medicine, Kuwait University, Safat, Kuwait. 
      segunade@yahoo.com
FAU - Al Mulla, Fahd
AU  - Al Mulla F
FAU - Abdella, Nabila A
AU  - Abdella NA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090210
PL  - Switzerland
TA  - Med Princ Pract
JT  - Medical principles and practice : international journal of the Kuwait University, 
      Health Science Centre
JID - 8901334
RN  - 0 (Adipokines)
SB  - IM
MH  - Adipokines/*blood
MH  - Body Mass Index
MH  - Body Weights and Measures
MH  - Coronary Disease/complications/*etiology
MH  - Diabetes Mellitus, Type 2/complications/*metabolism
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Male
MH  - Metabolic Syndrome
MH  - Middle Aged
MH  - Obesity/*diagnosis
MH  - ROC Curve
EDAT- 2009/02/11 09:00
MHDA- 2009/05/09 09:00
CRDT- 2009/02/11 09:00
PHST- 2008/04/28 00:00 [received]
PHST- 2008/07/20 00:00 [accepted]
PHST- 2009/02/11 09:00 [entrez]
PHST- 2009/02/11 09:00 [pubmed]
PHST- 2009/05/09 09:00 [medline]
AID - 000189810 [pii]
AID - 10.1159/000189810 [doi]
PST - ppublish
SO  - Med Princ Pract. 2009;18(2):123-9. doi: 10.1159/000189810. Epub 2009 Feb 10.