PMID- 19205731
OWN - NLM
STAT- MEDLINE
DCOM- 20091012
LR  - 20151119
IS  - 1863-2661 (Electronic)
IS  - 1863-2653 (Linking)
VI  - 213
IP  - 6
DP  - 2009 Oct
TI  - Brain volumes and Val66Met polymorphism of the BDNF gene: local or global 
      effects?
PG  - 501-9
LID - 10.1007/s00429-009-0203-y [doi]
AB  - A common Single-Nucleotide Polymorphism in the Brain-Derived Neurotrophic Factor 
      (BDNF) gene coding the Val66Met substitution in the pro-BDNF protein has been 
      associated with a number of behavioural and neuroanatomical phenotypes; the 
      latter include, for example, regional differences in volumes of the hippocampus 
      and prefrontal grey matter. Here, we show that the observed regional differences 
      may not stem from a localised effect of this gene. Our analysis of regional brain 
      volume in a cohort of 331 adolescents indicates that the Val66Met substitution 
      has a global effect on brain volume, and that the observed local differences are 
      to be expected if brain allometry-the covariance pattern of regional brain 
      volumes-is taken into account.
FAU - Toro, Roberto
AU  - Toro R
AD  - Brain and Body Centre, University of Nottingham, Nottingham, UK. rto@pasteur.fr
FAU - Chupin, Marie
AU  - Chupin M
FAU - Garnero, Line
AU  - Garnero L
FAU - Leonard, Gabriel
AU  - Leonard G
FAU - Perron, Michel
AU  - Perron M
FAU - Pike, Bruce
AU  - Pike B
FAU - Pitiot, Alain
AU  - Pitiot A
FAU - Richer, Louis
AU  - Richer L
FAU - Veillette, Suzanne
AU  - Veillette S
FAU - Pausova, Zdenka
AU  - Pausova Z
FAU - Paus, Tomas
AU  - Paus T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090210
PL  - Germany
TA  - Brain Struct Funct
JT  - Brain structure & function
JID - 101282001
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Protein Precursors)
RN  - 0 (brain-derived neurotrophic factor precursor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
EIN - Brain Struct Funct. 2009 Dec;214(1):87
MH  - Adolescent
MH  - Brain/*anatomy & histology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Interviews as Topic
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Methionine/genetics
MH  - Organ Size
MH  - Polymorphism, Single Nucleotide
MH  - Protein Precursors/*genetics
MH  - Surveys and Questionnaires
MH  - Valine/genetics
MH  - Young Adult
EDAT- 2009/02/12 09:00
MHDA- 2009/10/13 06:00
CRDT- 2009/02/12 09:00
PHST- 2009/01/14 00:00 [received]
PHST- 2009/01/15 00:00 [accepted]
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/10/13 06:00 [medline]
AID - 10.1007/s00429-009-0203-y [doi]
PST - ppublish
SO  - Brain Struct Funct. 2009 Oct;213(6):501-9. doi: 10.1007/s00429-009-0203-y. Epub 
      2009 Feb 10.