PMID- 19205764
OWN - NLM
STAT- MEDLINE
DCOM- 20090727
LR  - 20211020
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Print)
IS  - 0934-9723 (Linking)
VI  - 28
IP  - 7
DP  - 2009 Jul
TI  - Sequential analysis of biomarkers in cerebrospinal fluid and serum during 
      invasive meningococcal disease.
PG  - 793-9
LID - 10.1007/s10096-009-0708-6 [doi]
AB  - The aim of the present study was to determine the profile of different 
      inflammatory molecules in serum and cerebrospinal fluid (CSF) during invasive 
      meningococcal disease (IMD). Their relationship with IMD severity was also 
      assessed. A cohort of 12 patients with IMD was investigated. Paired serum and CSF 
      samples were obtained at the time of diagnostic and follow-up lumbar puncture and 
      were examined using Luminex analysis. IMD severity correlated with serum 
      interleukin-6 (IL-6) and interleukin-1 receptor antagonist (IL-1 ra) on 
      admission. Furthermore, the CSF levels of IL-1 beta, IL-1 ra, IL-6, IL-8, 
      macrophage inflammatory protein-1 beta (MIP-1 beta), and monocyte chemoattractant 
      protein-1 (MCP-1) were significantly higher than their respective serum levels. 
      The strongest correlations were found between serum concentrations of IL-1 beta 
      and IL-1 ra, IL-6, IL-8, and MIP-1 beta, whereas the strongest correlations in 
      CSF were found between endotoxin and IL-8, IL-17, MIP-1 beta, and MCP-1. As was 
      expected, the concentrations of inflammatory molecules in both serum and CSF 
      significantly decreased after antibiotic treatment. With regard to kinetics, a 
      severe course of IMD correlated positively with rapid declines of CSF IL-6 and 
      cortisol levels. Sequential multiple analyses revealed patterns of inflammatory 
      responses that were associated with the severity of IMD, as well as with the 
      compartmentalization and kinetics of the immune reaction.
FAU - Beran, O
AU  - Beran O
AD  - 1st Medical Faculty, Teaching Hospital Bulovka, 3rd Department of Infectious and 
      Tropical Diseases, Charles University in Prague, Prague, Czech Republic.
FAU - Lawrence, D A
AU  - Lawrence DA
FAU - Andersen, N
AU  - Andersen N
FAU - Dzupova, O
AU  - Dzupova O
FAU - Kalmusova, J
AU  - Kalmusova J
FAU - Musilek, M
AU  - Musilek M
FAU - Holub, M
AU  - Holub M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090210
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official 
      publication of the European Society of Clinical Microbiology
JID - 8804297
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Biomarkers)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Anti-Bacterial Agents/therapeutic use
MH  - Biomarkers
MH  - Cerebrospinal Fluid/*chemistry
MH  - Female
MH  - Humans
MH  - Inflammation Mediators/*analysis
MH  - Male
MH  - Meningococcal Infections/drug therapy/microbiology/*pathology
MH  - Middle Aged
MH  - Serum/*chemistry
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC2693780
EDAT- 2009/02/12 09:00
MHDA- 2009/07/28 09:00
PMCR- 2009/06/09
CRDT- 2009/02/12 09:00
PHST- 2008/10/01 00:00 [received]
PHST- 2009/01/15 00:00 [accepted]
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/07/28 09:00 [medline]
PHST- 2009/06/09 00:00 [pmc-release]
AID - 708 [pii]
AID - 10.1007/s10096-009-0708-6 [doi]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2009 Jul;28(7):793-9. doi: 
      10.1007/s10096-009-0708-6. Epub 2009 Feb 10.