PMID- 19207143
OWN - NLM
STAT- MEDLINE
DCOM- 20090302
LR  - 20090211
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Linking)
VI  - 57
IP  - 2
DP  - 2009 Feb
TI  - Predictors of mortality in home-dwelling patients with cardiovascular disease 
      aged 75 and older.
PG  - 279-84
LID - 10.1111/j.1532-5415.2008.02112.x [doi]
AB  - OBJECTIVES: To compare the predictive value of biomarkers commonly measured in 
      older patients with cardiovascular disease (CVD) with an indicator of cognitive 
      function. DESIGN: Prospective cohort study. SETTING: Helsinki, Finland. 
      PARTICIPANTS: Three hundred ninety-eight home-dwelling older persons (261 women, 
      mean age 80) with stable CVD and without a diagnosis of clinical dementia. 
      MEASUREMENTS: Simple laboratory and clinical measurements (including the Mini 
      Mental State Examination (MMSE, maximum score 30 points) and New York Heart 
      Association (NYHA) classification) were used to predict mortality. A MMSE score 
      between 18 and 24 points was considered to indicate cognitive impairment. 
      RESULTS: At baseline, median MMSE score was 27 (interquartile range 25-28), with 
      59 individuals having a score below 24 points. During a mean follow-up of 6.0 
      years, 129 participants died. In the fully adjusted Cox proportional hazards 
      model, low MMSE score was the strongest predictor of mortality, with a relative 
      hazard of 2.38 (95% confidence interval=1.52-3.74; P<.001). Of the various 
      clinical and laboratory variables, only creatinine, C-reactive protein, and 
      history of congestive heart failure were significant independent predictors, 
      whereas conventional risk factors were not. CONCLUSION: Only a few clinical 
      variables independently predicted 6-year mortality in older home-living patients 
      with CVD. The strongest predictor was impaired cognitive function assessed using 
      MMSE.
FAU - Strandberg, Timo E
AU  - Strandberg TE
AD  - Department of Health Sciences/Geriatrics, University of Oulu, Oulu University 
      Hospital, Finland. timo.strandberg@oulu.fi
FAU - Pitkala, Kaisu H
AU  - Pitkala KH
FAU - Tilvis, Reijo S
AU  - Tilvis RS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
SB  - IM
MH  - Aged
MH  - Cardiovascular Diseases/*mortality
MH  - Cognition Disorders/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Status Schedule
EDAT- 2009/02/12 09:00
MHDA- 2009/03/03 09:00
CRDT- 2009/02/12 09:00
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/03/03 09:00 [medline]
AID - JGS2112 [pii]
AID - 10.1111/j.1532-5415.2008.02112.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2009 Feb;57(2):279-84. doi: 10.1111/j.1532-5415.2008.02112.x.