PMID- 19207378
OWN - NLM
STAT- MEDLINE
DCOM- 20090529
LR  - 20131121
IS  - 1600-0536 (Electronic)
IS  - 0105-1873 (Linking)
VI  - 60
IP  - 2
DP  - 2009 Feb
TI  - Assessment of the sensitization potential of persulfate salts used for bleaching 
      hair.
PG  - 85-90
LID - 10.1111/j.1600-0536.2008.01477.x [doi]
AB  - BACKGROUND: Persulfate salts have been associated with both allergic contact 
      dermatitis and bronchial asthma. Because there is currently no experimental data 
      available on the sensitizing properties of persulfate salts (ammonium, sodium, 
      and potassium persulfates), we determined their dermal sensitizing capacity, 
      using the murine local lymph node assay (LLNA). MATERIAL AND METHODS: For three 
      consecutive days, BALB/c mice were dermally treated with ammonium, sodium, or 
      potassium persulfate or with the vehicle alone (dimethyl sulfoxide) on each ear 
      (2 x 25 microl). On D6, mice were injected intravenously with [(3)H]-methyl 
      thymidine. The draining auricular lymph nodes were removed, and the incorporation 
      of [(3)H]-methyl thymidine was compared with that of vehicle-treated control 
      mice. A stimulation index (SI) relative to the vehicle-treated control value was 
      derived. The sensitizing potency of the chemicals tested was determined by 
      estimating the concentration of chemical required to induce a SI of 3 (EC3). 
      RESULTS: All three chemicals provoked positive responses in the LLNA, with 
      dose-dependent increases in proliferation. Maximal SIs recorded were 6.8 +/- 1.8, 
      6.5 +/- 1.2, and 5 +/- 1.0 at 5% for ammonium, sodium or potassium persulfate, 
      respectively. The EC3 values were 1.9%, 0.9%, and 2.4% for ammonium, sodium, and 
      potassium persulfates, respectively. CONCLUSIONS: All three persulfate salts need 
      to be considered strong-to-moderate sensitizers according to the murine LLNA.
FAU - Cruz, Maria-Jesus
AU  - Cruz MJ
AD  - CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. 
      mjcruz@ir.vhebron.net
FAU - De Vooght, Vanessa
AU  - De Vooght V
FAU - Munoz, Xavier
AU  - Munoz X
FAU - Hoet, Peter H M
AU  - Hoet PH
FAU - Morell, Ferran
AU  - Morell F
FAU - Nemery, Benoit
AU  - Nemery B
FAU - Vanoirbeek, J A J
AU  - Vanoirbeek JA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Contact Dermatitis
JT  - Contact dermatitis
JID - 7604950
RN  - 0 (Allergens)
RN  - 0 (Hair Dyes)
RN  - 0 (Potassium Compounds)
RN  - 0 (Sulfates)
RN  - 22QF6L357F (ammonium peroxydisulfate)
RN  - 6B86K0MCZC (potassium persulfate)
RN  - SU46BAM238 (Ammonium Sulfate)
SB  - IM
MH  - Allergens/toxicity
MH  - Ammonium Sulfate/toxicity
MH  - Animals
MH  - Dermatitis, Allergic Contact/*diagnosis/*etiology
MH  - Hair Dyes/*toxicity
MH  - Local Lymph Node Assay
MH  - Lymphocyte Activation/drug effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Potassium Compounds/toxicity
MH  - Skin Irritancy Tests/methods
MH  - Sulfates/*toxicity
EDAT- 2009/02/12 09:00
MHDA- 2009/05/30 09:00
CRDT- 2009/02/12 09:00
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/05/30 09:00 [medline]
AID - COD1477 [pii]
AID - 10.1111/j.1600-0536.2008.01477.x [doi]
PST - ppublish
SO  - Contact Dermatitis. 2009 Feb;60(2):85-90. doi: 10.1111/j.1600-0536.2008.01477.x.