PMID- 19207611
OWN - NLM
STAT- MEDLINE
DCOM- 20090715
LR  - 20151119
IS  - 1442-2042 (Electronic)
IS  - 0919-8172 (Linking)
VI  - 16
IP  - 3
DP  - 2009 Mar
TI  - Estrogen receptor-binding fragment-associated gene 9 expression and its clinical 
      significance in human testicular cancer.
PG  - 329-32
LID - 10.1111/j.1442-2042.2008.02233.x [doi]
AB  - OBJECTIVES: We previously demonstrated that estrogen receptor-binding 
      fragment-associated gene 9 (EBAG9) is a tumor promoting factor in renal cell 
      carcinoma (Ogushi T, Cancer Res. 2005; 65: 3700). Here, we evaluated EBAG9 
      expression and its clinical significance in normal and malignant human testicular 
      tissues. METHODS: We investigated the expression of EBAG9 in 90 testicular 
      specimens (28 benign testicular tissue and 62 testicular germ cell tumor samples) 
      by immunohistochemistry using rabbit polyclonal anti-EBAG9 antibody. RESULTS: 
      Positive immunostaining of EBAG9 in the cytoplasm was found in 32 (52%) cancerous 
      lesions, whereas the immunoreactivity of EBAG9 was weak in benign testicular 
      tissues. Serum lactate dehydrogenaze (LDH) level was significantly higher in 
      EBAG9-positive cases (715.0 +/- 727.3) compared with the negative cases (221.4 
      +/- 126.8) (P = 0.0016). The EBAG9-positive cases among the patients with 
      advanced clinical stage (Stage II and III) more frequently belonged to the 
      intermediate or poor risk group in the International Germ Cell Consensus 
      Prognostic Classification System (IGCCPCS), compared with the EBAG9-negative 
      cases (P = 0.0012). CONCLUSIONS: These findings suggest that increased expression 
      of EBAG9 may play a significant role in cancer progression and aggressiveness in 
      testicular germ cell tumors.
FAU - Fujimura, Tetsuya
AU  - Fujimura T
AD  - Department of Urology, Faculty of Medicine, The University of Tokyo, Tokyo, 
      Japan.
FAU - Takahashi, Satoru
AU  - Takahashi S
FAU - Urano, Tomohiko
AU  - Urano T
FAU - Xiaoqiang, Liu
AU  - Xiaoqiang L
FAU - Ogushi, Tetsuo
AU  - Ogushi T
FAU - Muramatsu, Masami
AU  - Muramatsu M
FAU - Ouchi, Yasuyoshi
AU  - Ouchi Y
FAU - Kitamura, Tadaichi
AU  - Kitamura T
FAU - Homma, Yukio
AU  - Homma Y
FAU - Inoue, Satoshi
AU  - Inoue S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090120
PL  - Australia
TA  - Int J Urol
JT  - International journal of urology : official journal of the Japanese Urological 
      Association
JID - 9440237
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (EBAG9 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Antigens, Neoplasm/*genetics/metabolism
MH  - Biomarkers, Tumor/genetics
MH  - Cohort Studies
MH  - Frozen Sections
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Germ Cell and Embryonal/*genetics/pathology/surgery
MH  - Orchiectomy/methods
MH  - Probability
MH  - Prognosis
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Sensitivity and Specificity
MH  - Statistics, Nonparametric
MH  - Survival Analysis
MH  - Testicular Neoplasms/*genetics/mortality/pathology/surgery
MH  - Young Adult
EDAT- 2009/02/12 09:00
MHDA- 2009/07/16 09:00
CRDT- 2009/02/12 09:00
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/07/16 09:00 [medline]
AID - IJU2233 [pii]
AID - 10.1111/j.1442-2042.2008.02233.x [doi]
PST - ppublish
SO  - Int J Urol. 2009 Mar;16(3):329-32. doi: 10.1111/j.1442-2042.2008.02233.x. Epub 
      2009 Jan 20.