PMID- 19208505
OWN - NLM
STAT- MEDLINE
DCOM- 20090512
LR  - 20220410
IS  - 1744-165X (Print)
IS  - 1744-165X (Linking)
VI  - 14
IP  - 2
DP  - 2009 Apr
TI  - Offspring of diabetic pregnancy: long-term outcomes.
PG  - 119-24
LID - 10.1016/j.siny.2009.01.002 [doi]
AB  - Diabetes in pregnancy has been shown to induce long-term effects in offspring. 
      While considerable attention is focused on the increased incidence of type 2 
      diabetes mellitus (T2DM) in adult offspring from diabetic mothers, cardiovascular 
      alterations, including hypertension, are also part of lifelong consequences of 
      in-utero exposure to increased glucose concentrations. This review examines the 
      epidemiologic and mechanistic issues involved in the developmental programming of 
      long-term consequences in offspring of diabetic mothers, with a particular 
      emphasis on the renal and vascular mechanisms of hypertension. The factors of 
      increased incidence of T2DM and of obesity in adults born after exposure to 
      diabetes during pregnancy are also discussed, as evidence is accumulating that a 
      vicious circle involving lifelong consequences of diabetes in pregnancy in 
      offspring contributes to the current worldwide epidemic of T2DM.
FAU - Simeoni, Umberto
AU  - Simeoni U
AD  - INSERM UMR608, Universite de la Mediterranee, France; Faculte de Medecine, 
      Universite de la Mediterranee, France; Division of Neonatology, Assistance 
      Publique-Hopitaux de Marseille, France. umberto.simeoni@ap-hm.fr
FAU - Barker, David J
AU  - Barker DJ
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090208
PL  - Netherlands
TA  - Semin Fetal Neonatal Med
JT  - Seminars in fetal & neonatal medicine
JID - 101240003
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Diabetes Mellitus, Type 2/etiology
MH  - Female
MH  - Humans
MH  - Hyperglycemia/*complications
MH  - Hypertension/etiology
MH  - Insulin Resistance
MH  - Obesity/etiology
MH  - Pregnancy
MH  - *Pregnancy in Diabetics
MH  - *Prenatal Exposure Delayed Effects
MH  - Young Adult
RF  - 64
EDAT- 2009/02/12 09:00
MHDA- 2009/05/13 09:00
CRDT- 2009/02/12 09:00
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/05/13 09:00 [medline]
AID - S1744-165X(09)00003-1 [pii]
AID - 10.1016/j.siny.2009.01.002 [doi]
PST - ppublish
SO  - Semin Fetal Neonatal Med. 2009 Apr;14(2):119-24. doi: 10.1016/j.siny.2009.01.002. 
      Epub 2009 Feb 8.