PMID- 19209189
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20211020
IS  - 1476-5438 (Electronic)
IS  - 1018-4813 (Print)
IS  - 1018-4813 (Linking)
VI  - 17
IP  - 8
DP  - 2009 Aug
TI  - Two British women studies replicated the association between the Val66Met 
      polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI.
PG  - 1050-5
LID - 10.1038/ejhg.2008.272 [doi]
AB  - The goal of this study is to investigate the relationship between the Val66Met 
      polymorphism in the brain-derived neurotrophic factor (BDNF) and body mass index 
      (BMI) in two sizable and well-characterized populations of British women: the 
      British Women's Heart and Health Study (BWHHS) (age 60-79 years) and the mothers 
      from the Avon Longitudinal Study of Parents and Children (age 16-44 years). We 
      genotyped the Val66Met polymorphism (rs6265) in these two populations, and 
      conducted a linear regression analysis to test for an association between this 
      polymorphism and BMI. Both study populations indicated an association between BMI 
      and the Val66Met polymorphism, with individuals carrying the Met-Met genotype 
      having a lower mean BMI than those with the Val-Met or Val-Val genotypes (in the 
      BWHHS): mean BMI difference=-0.911 kg/m(2), 95% confidence interval (CI): -1.70 
      to -0.12, P=0.023; in the mothers from the Avon Longitudinal Study of Parents and 
      Children (ALSPAC): mean BMI difference=-0.57 kg/m(2), 95%CI: -1.08 to -0.054, 
      P=0.03). In a pooled analysis of these two studies, together with one further 
      published study that provided data in a suitable format for inclusion in our 
      meta-analysis, we found a pooled difference of -0.76 (95% CI: -1.16, -0.036) for 
      adult women; I(2)-test for heterogeneity=51%, P=0.13. Our study indicated an 
      association between BDNF and BMI in two general population studies of women. The 
      exact role of BDNF in weight regulation merits further investigation.
FAU - Shugart, Yin Yao
AU  - Shugart YY
AD  - Department of Epidemiology, Johns Hopkins University, Baltimore, MD 21205, USA. 
      kay1yao@mail.nih.gov
FAU - Chen, Lina
AU  - Chen L
FAU - Day, Ian N M
AU  - Day IN
FAU - Lewis, Sarah J
AU  - Lewis SJ
FAU - Timpson, Nicholas J
AU  - Timpson NJ
FAU - Yuan, Wei
AU  - Yuan W
FAU - Abdollahi, Mohammad Reza
AU  - Abdollahi MR
FAU - Ring, Sue M
AU  - Ring SM
FAU - Ebrahim, Shah
AU  - Ebrahim S
FAU - Golding, Jean
AU  - Golding J
FAU - Lawlor, Debbie A
AU  - Lawlor DA
FAU - Davey-Smith, George
AU  - Davey-Smith G
LA  - eng
GR  - G0600705/MRC_/Medical Research Council/United Kingdom
GR  - G9815508/MRC_/Medical Research Council/United Kingdom
GR  - WT_/Wellcome Trust/United Kingdom
GR  - BHF_/British Heart Foundation/United Kingdom
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20090211
PL  - England
TA  - Eur J Hum Genet
JT  - European journal of human genetics : EJHG
JID - 9302235
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Amino Acid Substitution
MH  - *Body Mass Index
MH  - Body Weight/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Methionine/genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide/physiology
MH  - United Kingdom
MH  - Valine/genetics
MH  - Young Adult
PMC - PMC2986560
EDAT- 2009/02/12 09:00
MHDA- 2009/10/09 06:00
PMCR- 2009/08/01
CRDT- 2009/02/12 09:00
PHST- 2009/02/12 09:00 [entrez]
PHST- 2009/02/12 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
PHST- 2009/08/01 00:00 [pmc-release]
AID - ejhg2008272 [pii]
AID - 10.1038/ejhg.2008.272 [doi]
PST - ppublish
SO  - Eur J Hum Genet. 2009 Aug;17(8):1050-5. doi: 10.1038/ejhg.2008.272. Epub 2009 Feb 
      11.