PMID- 1921021
OWN - NLM
STAT- MEDLINE
DCOM- 19911120
LR  - 20190817
IS  - 0021-5287 (Print)
IS  - 0021-5287 (Linking)
VI  - 82
IP  - 8
DP  - 1991 Aug
TI  - [Cyclosporine induced nephrotoxicity and juxtaglomerular apparatus in mice].
PG  - 1286-91
AB  - To elucidate the relationship between Cyclosporine (Cs) induced nephrotoxicity 
      and juxtaglomerular (JG) apparatus, we carried out biochemical and morphological 
      experiments using mice. Adult male ICR strain mice weighing about 40 g were used. 
      The mice were divided into 2 groups: the Cs group (Cs 50 mg/kg/day was orally 
      given for 14 consecutive days) and the control group (olive oil for 14 days). 
      Urine was stored for 24 hours on the day 0, 7 and 14 and urine volume and 
      concentrations of urinary creatinine (u-Cr) and urinary potassium (u-K) were 
      measured in each group. All the mice were sacrificed and examined on the 15th 
      day. Concentrations of serum creatinine (s-Cr), serum potassium (s-K), plasma 
      renin activity (PRA), plasma aldosterone (Ald) were noted in each group. The 
      kidneys were also examined histologically with light and electron microscopes. 
      The Cs group showed significant increases of s-K, PRA and Ald and a significant 
      decrease of creatinine clearance compared with the control group. Histologically, 
      the Cs group demonstrated focal vacuolar changes in the proximal tubular cells 
      and an increase in the number of granules in the JG cells. Each granule of the Cs 
      group was larger than that of the control group. Cs certainly stimulates the 
      renin-angiotensin-aldosterone system and causes consequently a secondary 
      aldosteronism.
FAU - Ishikawa, A
AU  - Ishikawa A
AD  - Department of Urology, Hamamatsu University School of Medicine.
FAU - Sakaguchi, M
AU  - Sakaguchi M
FAU - Nakano, M
AU  - Nakano M
FAU - Ushiyama, T
AU  - Ushiyama T
FAU - Ohta, N
AU  - Ohta N
FAU - Ohtawara, Y
AU  - Ohtawara Y
FAU - Tajima, A
AU  - Tajima A
FAU - Kawabe, K
AU  - Kawabe K
FAU - Aso, Y
AU  - Aso Y
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Nihon Hinyokika Gakkai Zasshi
JT  - Nihon Hinyokika Gakkai zasshi. The japanese journal of urology
JID - 2984841R
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - AYI8EX34EU (Creatinine)
RN  - EC 3.4.23.15 (Renin)
RN  - RWP5GA015D (Potassium)
SB  - IM
MH  - Animals
MH  - Creatinine/urine
MH  - Cyclosporine/*toxicity
MH  - Hyperaldosteronism/chemically induced
MH  - Juxtaglomerular Apparatus/*drug effects/pathology
MH  - Kidney/*drug effects/pathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Potassium/urine
MH  - Renin/blood
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.5980/jpnjurol1989.82.1286 [doi]
PST - ppublish
SO  - Nihon Hinyokika Gakkai Zasshi. 1991 Aug;82(8):1286-91. doi: 
      10.5980/jpnjurol1989.82.1286.