PMID- 19210370
OWN - NLM
STAT- MEDLINE
DCOM- 20090623
LR  - 20161125
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 6
DP  - 2009 Jun
TI  - Aluminium per se and in the anti-acid drug sucralfate promotes sensitization via 
      the oral route.
PG  - 890-7
LID - 10.1111/j.1398-9995.2008.01933.x [doi]
AB  - BACKGROUND: Aluminium (ALUM) is used as experimental and clinical adjuvant for 
      parenteral vaccine formulation. It is also contained in anti-acid drugs like 
      sucralfate (SUC). These anti-acids have been shown to cause sensitization to food 
      proteins via elevation of the gastric pH. The aim of this study was to assess the 
      oral adjuvant properties of ALUM, alone or contained in SUC, in a BALB/c mouse 
      model. METHODS: Mice were fed SUC plus ovalbumin (OVA) and compared with groups 
      where ALUM or proton pump inhibitors (PPI) were applied as adjuvants. The humoral 
      and cellular immune responses were assessed on antigen-specific antibody and 
      cytokine levels. The in vivo relevance was investigated in skin tests. RESULTS: 
      The highest OVA-specific immunoglobulin G1 (IgG1) and IgE antibody levels were 
      found in mice fed with OVA/SUC, followed by OVA/ALUM-treated animals, indicating 
      a T helper 2 (Th2) shift in both groups. Antibody levels in other groups revealed 
      lower (OVA/PPI-group) or baseline levels (control groups). Positive skin tests 
      confirmed an allergic response in anti-acid or adjuvant-treated animals. 
      CONCLUSIONS: Our data show for the first time that ALUM acts as a Th2-adjuvant 
      via the oral route. This suggests that orally applied SUC leads to an enhanced 
      risk for food allergy, not only by inhibiting peptic digestion but also by acting 
      as a Th2-adjuvant by its ALUM content.
FAU - Brunner, R
AU  - Brunner R
AD  - Department of Pathophysiology, Medical University of Vienna, Vienna, Austria.
FAU - Wallmann, J
AU  - Wallmann J
FAU - Szalai, K
AU  - Szalai K
FAU - Karagiannis, P
AU  - Karagiannis P
FAU - Altmeppen, H
AU  - Altmeppen H
FAU - Riemer, A B
AU  - Riemer AB
FAU - Jensen-Jarolim, E
AU  - Jensen-Jarolim E
FAU - Pali-Scholl, I
AU  - Pali-Scholl I
LA  - eng
PT  - Journal Article
DEP - 20090205
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Adjuvants, Immunologic)
RN  - 0 (Alum Compounds)
RN  - 0 (Antacids)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Interleukin-5)
RN  - 34S289N54E (aluminum sulfate)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 54182-58-0 (Sucralfate)
RN  - 82115-62-6 (Interferon-gamma)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Adjuvants, Immunologic/*adverse effects
MH  - Administration, Oral
MH  - Alum Compounds/*adverse effects
MH  - Animals
MH  - Antacids/*adverse effects
MH  - Female
MH  - Food Hypersensitivity/*etiology
MH  - Gastric Acidity Determination
MH  - Immunoglobulin E/blood
MH  - Immunoglobulin G/blood
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-5/biosynthesis
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Skin Tests
MH  - Sucralfate/*adverse effects
MH  - Th2 Cells/immunology
EDAT- 2009/02/13 09:00
MHDA- 2009/06/24 09:00
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/06/24 09:00 [medline]
AID - ALL1933 [pii]
AID - 10.1111/j.1398-9995.2008.01933.x [doi]
PST - ppublish
SO  - Allergy. 2009 Jun;64(6):890-7. doi: 10.1111/j.1398-9995.2008.01933.x. Epub 2009 
      Feb 5.