PMID- 19210522
OWN - NLM
STAT- MEDLINE
DCOM- 20090616
LR  - 20211020
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 156
IP  - 1
DP  - 2009 Apr
TI  - Monocyte-derived dendritic cells from patients with severe forms of 
      chromoblastomycosis induce CD4+ T cell activation in vitro.
PG  - 117-25
LID - 10.1111/j.1365-2249.2008.03870.x [doi]
AB  - Dendritic cells (DCs) have been described as initiators and modulators of the 
      immune response. Recently we have shown a predominant production of 
      interleukin-10 cytokine, low levels of interferon-gamma and inefficient T cell 
      proliferation in patients with severe forms of chromoblastomycosis. 
      Chromoblastomycosis starts with subcutaneous inoculation of Fonsecaea pedrosoi 
      into tissue where DCs are the first line of defence against this microorganism. 
      In the present study, the interaction of F. pedrosoi and DCs obtained from 
      patients with chromoblastomycosis was investigated. Our results showed that DCs 
      from patients exhibited an increased expression of human leucocyte antigen 
      D-related (HLA-DR) and co-stimulatory molecules. In the presence of conidia, the 
      expression of HLA-DR and CD86 was up-regulated by DCs from patients and controls. 
      Finally, we demonstrate the reversal of antigen-specific anergy and a T helper 
      type 1 response mediated by DCs incubated with F. pedrosoi conidea.
FAU - Sousa, M Gloria
AU  - Sousa MG
AD  - Departamento de Analises Clinicas e Toxicologicas, Faculdade de Ciencias 
      Farmaceuticas, Universidade de Sao Paulo, SP, Brazil.
FAU - Ghosn, E Eid Bou
AU  - Ghosn EE
FAU - Nascimento, R Ciciro
AU  - Nascimento RC
FAU - Bomfim, G Facchioli
AU  - Bomfim GF
FAU - Noal, V
AU  - Noal V
FAU - Santiago, K
AU  - Santiago K
FAU - de Maria Pedrozo E Silva Azevedo, C
AU  - de Maria Pedrozo E Silva Azevedo C
FAU - Marques, S Garcia
AU  - Marques SG
FAU - Goncalves, A Guedes
AU  - Goncalves AG
FAU - de Castro Lima Santos, D Wagner
AU  - de Castro Lima Santos DW
FAU - Criado, P Ricardo
AU  - Criado PR
FAU - Costa Martins, J Eduardo
AU  - Costa Martins JE
FAU - Almeida, S Rogerio
AU  - Almeida SR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090204
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Antigens, Fungal)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Cytokines)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, Fungal/immunology
MH  - B7-2 Antigen/metabolism
MH  - CD4-Positive T-Lymphocytes/*immunology
MH  - Cell Proliferation
MH  - Cells, Cultured
MH  - Chromoblastomycosis/*immunology
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/*immunology
MH  - Female
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Lymphocyte Activation/immunology
MH  - Male
MH  - Middle Aged
MH  - Mitosporic Fungi/immunology
MH  - Th1 Cells/immunology
MH  - Up-Regulation/immunology
PMC - PMC2673749
EDAT- 2009/02/13 09:00
MHDA- 2009/06/17 09:00
PMCR- 2010/04/01
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/06/17 09:00 [medline]
PHST- 2010/04/01 00:00 [pmc-release]
AID - CEI3870 [pii]
AID - 10.1111/j.1365-2249.2008.03870.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2009 Apr;156(1):117-25. doi: 10.1111/j.1365-2249.2008.03870.x. 
      Epub 2009 Feb 4.