PMID- 19210797
OWN - NLM
STAT- MEDLINE
DCOM- 20090311
LR  - 20220409
IS  - 1475-2875 (Electronic)
IS  - 1475-2875 (Linking)
VI  - 8
DP  - 2009 Feb 12
TI  - Estimating the burden of malaria in pregnancy: a case study from rural Madhya 
      Pradesh, India.
PG  - 24
LID - 10.1186/1475-2875-8-24 [doi]
AB  - BACKGROUND: Malaria in pregnancy (MiP) is inadequately researched in India, and 
      the burden is probably much higher than current estimates suggest. This paper 
      models the burden of MiP and associated foetal losses and maternal deaths, in 
      rural Madhya Pradesh, India. METHODS: Number of pregnancies per year was 
      estimated from the number of births and an estimate of pregnancies that end in 
      foetal loss. The prevalence of MiP, risk of foetal loss attributable to MiP and 
      case fatality rate of MiP were obtained from the literature. The estimated total 
      number of pregnancies was multiplied by the appropriate parameter to estimate the 
      number of MiP cases, and foetal loss and maternal deaths attributable to MiP per 
      year. A Monte Carlo simulation sensitivity analysis was done to assess 
      plausibility of various estimates obtained from the literature. The burden of MiP 
      in tribal women was explored by incorporating the variable prevalence of malaria 
      in tribal and non-tribal populations and in forested and non-forested regions 
      within Madhya Pradesh. RESULTS: Estimates of MiP cases in rural Madhya Pradesh 
      based on the model parameter values found in the literature ranged from 
      183,000-1.5 million per year, with 73,000-629,000 lost foetuses and 1,500-12,600 
      maternal deaths attributable to MiP. The Monte Carlo simulation gave a more 
      plausible estimate of 220,000 MiP cases per year (inter-quartile range (IQR): 
      136,000-305,000), 95,800 lost foetuses (IQR: 56,800-147,600) and 1,000 maternal 
      deaths (IQR: 650-1,600). Tribal women living in forested areas bore 30% of the 
      burden of MiP in Madhya Pradesh, while constituting 18% of the population. 
      CONCLUSION: Although the estimates are uncertain, they suggest MiP is a 
      significant public health problem in rural Madhya Pradesh, affecting many 
      thousands of women and that reducing the MiP burden should be a priority.
FAU - Diamond-Smith, Nadia
AU  - Diamond-Smith N
AD  - London School of Hygiene and Tropical Medicine, London, UK. 
      nadia.diamondsmith@gmail.com
FAU - Singh, Neeru
AU  - Singh N
FAU - Gupta, R K Das
AU  - Gupta RK
FAU - Dash, Aditya
AU  - Dash A
FAU - Thimasarn, Krongthong
AU  - Thimasarn K
FAU - Campbell, Oona M R
AU  - Campbell OM
FAU - Chandramohan, Daniel
AU  - Chandramohan D
LA  - eng
PT  - Journal Article
DEP - 20090212
PL  - England
TA  - Malar J
JT  - Malaria journal
JID - 101139802
SB  - IM
MH  - Animals
MH  - Cost of Illness
MH  - Female
MH  - Fetal Death/epidemiology
MH  - Humans
MH  - India/epidemiology
MH  - Infant, Newborn
MH  - Malaria/*epidemiology/parasitology
MH  - *Maternal Mortality
MH  - Monte Carlo Method
MH  - Parasitemia/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Parasitic/*epidemiology
MH  - Pregnancy Outcome/*epidemiology
MH  - Prevalence
MH  - Risk Factors
MH  - Rural Population
PMC - PMC2647551
EDAT- 2009/02/13 09:00
MHDA- 2009/03/12 09:00
PMCR- 2009/02/12
CRDT- 2009/02/13 09:00
PHST- 2008/04/17 00:00 [received]
PHST- 2009/02/12 00:00 [accepted]
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/03/12 09:00 [medline]
PHST- 2009/02/12 00:00 [pmc-release]
AID - 1475-2875-8-24 [pii]
AID - 10.1186/1475-2875-8-24 [doi]
PST - epublish
SO  - Malar J. 2009 Feb 12;8:24. doi: 10.1186/1475-2875-8-24.