PMID- 19210864
OWN - NLM
STAT- MEDLINE
DCOM- 20090406
LR  - 20191210
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 26
IP  - 6
DP  - 2008 Nov-Dec
TI  - Lack of correlation of the health assessment questionnaire disability index with 
      lung parameters in systemic sclerosis associated pulmonary arterial hypertension.
PG  - 1012-7
AB  - OBJECTIVE: Pulmonary arterial hypertension (PAH) affects the quality of life 
      (QoL) and the ability to perform the activities of daily living (ADLs) in 
      patients with systemic sclerosis (SSc). We determined whether the Health 
      Assessment Questionnaire-Disability Index (HAQ-DI), a self-assessment measure of 
      function, correlates with a patient's PAH status in a population of SSc patients 
      with PAH. METHODS: Forty-one patients from one centre with systemic scleroderma, 
      dyspnea and PAH were included. All patients filled in a HAQ-DI, and underwent 
      evaluation with pulmonary function tests (PFTs), 6-minute walk distance (6MWD), 
      degree of dyspnea (Borg dyspnea index), NYHA functional class, and expert PAH 
      physician global assessment every 6 months. Change in HAQ DI was studied to 
      determine relationship to changes in PAH. RESULTS: The HAQ-DI scores had no 
      significant correlation with PAH, including NYHA functional class (r=0.38, 
      p=0.39), Borg dyspnea index (r=0.60, p=0.37), 6MWD (r=-0.04, p=0.86), % predicted 
      DLCO (r=0.31, p=0.25), % predicted FVC (r=0.02, p=0.93), and expert PAH physician 
      global assessment (r=0.06, p=0.97). CONCLUSION: HAQ-DI is not an adequate measure 
      of PAH status in SSc patients with PAH. Although PAH causes severe morbidity and 
      death, changes in PAH severity were not reflected in an overall functional status 
      change as assessed by the HAQ-DI. Thus, HAQ-DI changes do not reflect PAH status 
      in SSc.
FAU - Chow, S
AU  - Chow S
AD  - Departments of Rheumatology and Respirology, Schulich School of Medicine, 
      University of Western Ontario, London, Ontario, Canada.
FAU - Pope, J E
AU  - Pope JE
FAU - Mehta, S
AU  - Mehta S
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Disability Evaluation
MH  - Dyspnea/epidemiology/physiopathology
MH  - Health Status
MH  - Humans
MH  - Hypertension, Pulmonary/epidemiology/*physiopathology
MH  - Middle Aged
MH  - Morbidity
MH  - Predictive Value of Tests
MH  - Reproducibility of Results
MH  - Risk Factors
MH  - Scleroderma, Systemic/epidemiology/*physiopathology
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires/*standards
EDAT- 2009/02/13 09:00
MHDA- 2009/04/07 09:00
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/04/07 09:00 [medline]
AID - 2517 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2008 Nov-Dec;26(6):1012-7.