PMID- 19210880
OWN - NLM
STAT- MEDLINE
DCOM- 20090406
LR  - 20170112
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 26
IP  - 6
DP  - 2008 Nov-Dec
TI  - Serum levels of antibodies to Chlamydia pneumoniae and human HSP60 in giant cell 
      arteritis patients.
PG  - 1107-10
AB  - OBJECTIVE: To measure the serum levels of IgG anti-Chlamydia pneumoniae (C. 
      pneumoniae) and human heat shock protein (hHSP) 60 antibodies in patients with 
      active giant cell arteritis (GCA) and to determine whether such levels decrease 
      with corticosteroid therapy and remission of symptoms. METHODS: IgG anti-C. 
      pneumoniae and anti-hHSP60 antibodies were quantified by commercial and in-house 
      ELISA tests, respectively, in serum samples from 17 GCA patients, 39 polymyalgia 
      rheumatica (PMR) patients and 23 age-matched healthy subjects. RESULTS: Serum IgG 
      anti-hHSP60, but not anti-C. pneumoniae, antibodies were significantly increased 
      in GCA patients in comparison with PMR patients or healthy controls. After 
      steroid therapy, both anti-hHSP60 and -C. pneumoniae antibodies decreased 
      significantly in both groups of patients. CONCLUSIONS: Although some infectious 
      agents have been suggested to participate in GCA pathogenesis, our data do not 
      suggest that C. pneumoniae might be one of them. The production of anti-hHSP60 
      antibodies is shared in GCA with other systemic diseases and may be triggered by 
      unknown infectious agents and/or other inflammatory factors.
FAU - Lopez-Hoyos, M
AU  - Lopez-Hoyos M
AD  - Divisions of Immunology, Hospital Universitario Marques de Valdecilla, Spain. 
      inmlhm@humv.es
FAU - Alvarez, L
AU  - Alvarez L
FAU - Ruiz Soto, M
AU  - Ruiz Soto M
FAU - Blanco, R
AU  - Blanco R
FAU - Jose Bartolome, M
AU  - Jose Bartolome M
FAU - Martinez-Taboada, V M
AU  - Martinez-Taboada VM
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Antibodies, Bacterial)
RN  - 0 (Autoantibodies)
RN  - 0 (Chaperonin 60)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Steroids)
SB  - IM
MH  - Aged
MH  - Antibodies, Bacterial/blood
MH  - Autoantibodies/*blood
MH  - Chaperonin 60/*immunology
MH  - Chlamydophila Infections/*immunology
MH  - Chlamydophila pneumoniae/*immunology
MH  - Female
MH  - Giant Cell Arteritis/drug therapy/epidemiology/*immunology
MH  - Humans
MH  - Immunoglobulin G/blood
MH  - Male
MH  - Polymyalgia Rheumatica/drug therapy/epidemiology/immunology
MH  - Remission Induction
MH  - Risk Factors
MH  - Seroepidemiologic Studies
MH  - Steroids/therapeutic use
EDAT- 2009/02/13 09:00
MHDA- 2009/04/07 09:00
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/04/07 09:00 [medline]
AID - 2533 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2008 Nov-Dec;26(6):1107-10.