PMID- 19211151
OWN - NLM
STAT- MEDLINE
DCOM- 20090903
LR  - 20090317
IS  - 1872-7603 (Electronic)
IS  - 0165-0378 (Linking)
VI  - 79
IP  - 2
DP  - 2009 Jan
TI  - Antiphospholipid antibodies increase the risk of pregnancy-induced hypertension 
      and adverse pregnancy outcomes.
PG  - 188-95
LID - 10.1016/j.jri.2008.11.001 [doi]
AB  - Antiphospholipid antibody (aPL) is associated with thromboembolism. There is 
      scant evidence of a relationship between the aPL profile and serious adverse 
      pregnancy outcome. The aim of this study was to assess whether aPL measurements 
      during early pregnancy were useful in predicting a serious adverse pregnancy 
      outcome. In this prospective study, we measured aPLs, including lupus 
      anticoagulant (LA), IgG, IgM, IgA anticardiolipin antibody (aCL), IgG, IgM 
      phosphatidylserine-dependent antiprothrombin antibody, and IgG 
      kininogen-dependent antiphosphatidylethanolamine antibody (aPE) during the first 
      trimester in a consecutive series of 1155 women. The 99 th percentile cut-off 
      values in each aPL were determined using samples from 105 women who did not 
      exhibit any pregnancy morbidity. We assessed the predictive risk of a serious 
      adverse pregnancy outcome adjusted for confounding factors. We found that IgG aCL 
      was associated with developing pregnancy-induced hypertension (PIH) (odds ratio 
      11.4, 95% CI 2.7-48); IgG aPE with PIH (8.3, 2.4-29), severe PIH (20.4, 4.5-91), 
      and premature delivery (PD) (12.7, 3.1-50); and LA with PD (11.0, 2.8-44) and low 
      birth weight (8.0, 2.1-31). The combinations of IgG aPE plus IgG aCL (17.5, 
      4.7-66.7) or IgG aPE plus LA (22.2, 5.4-909) measurements predicted severe PIH 
      with 30.8% sensitivity and 99.2% specificity. We conclude that aPL measurements 
      during early pregnancy may be useful in predicting adverse pregnancy outcome.
FAU - Yamada, Hideto
AU  - Yamada H
AD  - Department of Obstetrics and Gynecology, Hokkaido University Graduate School of 
      Medicine, Kita-ku N15 W7, Sapporo 060-8638, Japan. yhideto@med.hokudai.ac.jp
FAU - Atsumi, Tatsuya
AU  - Atsumi T
FAU - Kobashi, Gen
AU  - Kobashi G
FAU - Ota, Chikako
AU  - Ota C
FAU - Kato, Emi H
AU  - Kato EH
FAU - Tsuruga, Noriko
AU  - Tsuruga N
FAU - Ohta, Kaori
AU  - Ohta K
FAU - Yasuda, Shinsuke
AU  - Yasuda S
FAU - Koike, Takao
AU  - Koike T
FAU - Minakami, Hisanori
AU  - Minakami H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090210
PL  - Ireland
TA  - J Reprod Immunol
JT  - Journal of reproductive immunology
JID - 8001906
RN  - 0 (Antibodies, Antiphospholipid)
SB  - IM
MH  - Adult
MH  - Antibodies, Antiphospholipid/*blood/*immunology
MH  - Female
MH  - Humans
MH  - Hypertension, Pregnancy-Induced/blood/*diagnosis/*immunology/physiopathology
MH  - Multivariate Analysis
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Risk Factors
EDAT- 2009/02/13 09:00
MHDA- 2009/09/04 06:00
CRDT- 2009/02/13 09:00
PHST- 2008/06/04 00:00 [received]
PHST- 2008/11/05 00:00 [revised]
PHST- 2008/11/11 00:00 [accepted]
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/09/04 06:00 [medline]
AID - S0165-0378(09)00002-3 [pii]
AID - 10.1016/j.jri.2008.11.001 [doi]
PST - ppublish
SO  - J Reprod Immunol. 2009 Jan;79(2):188-95. doi: 10.1016/j.jri.2008.11.001. Epub 
      2009 Feb 10.