PMID- 19211640
OWN - NLM
STAT- MEDLINE
DCOM- 20090622
LR  - 20211020
IS  - 1592-8721 (Electronic)
IS  - 0390-6078 (Print)
IS  - 0390-6078 (Linking)
VI  - 94
IP  - 3
DP  - 2009 Mar
TI  - Translocation t(11;14) and survival of patients with light chain (AL) 
      amyloidosis.
PG  - 380-6
LID - 10.3324/haematol.13369 [doi]
AB  - BACKGROUND: Light chain amyloidosis is a rare plasma cell dyscrasia. Interphase 
      fluorescence in situ hybridization (FISH) coupled to cytoplasmic staining of 
      specific Ig (cIg-FISH) on bone marrow plasma cells has become well established in 
      the initial evaluation of multiple myeloma, a related disorder. Little, however, 
      is known about cytogenetic abnormalities in patients with light chain 
      amyloidosis. DESIGN AND METHODS: We reviewed 56 patients with light chain 
      amyloidosis who had cIg-FISH performed as part of their routine clinical testing 
      using the standard screening panel employed in multiple myeloma at our 
      institution. RESULTS: Seventy percent of patients had abnormal cIg-FISH, with the 
      most common abnormalities being IgH translocations [48%]--including t(11;14) 
      [39%], and t(14;16) [2%]--and del13/del13q [30%]. No t(4;14) or deletions of 17p 
      (p53) were observed. Patients with t(11;14) had the lowest levels of clonal 
      plasma cells, and those with del13 had the highest. The risk of death for 
      patients harboring the t(11;14) translocation was 2.1 (CI 1.04-6.4), which on 
      multivariate analysis was independent of therapy. CONCLUSIONS: Although 
      preliminary, our data would suggest that cIg-FISH testing is important in 
      patients with light chain amyloidosis and that t(11;14) is an adverse prognostic 
      factor in these patients.
FAU - Bryce, Alan H
AU  - Bryce AH
AD  - Divison of Hematology, Mayo Clinic, 200 First Street, S.W., Rochester, MN 55905, 
      USA.
FAU - Ketterling, Rhett P
AU  - Ketterling RP
FAU - Gertz, Morie A
AU  - Gertz MA
FAU - Lacy, Martha
AU  - Lacy M
FAU - Knudson, Ryan A
AU  - Knudson RA
FAU - Zeldenrust, Steven
AU  - Zeldenrust S
FAU - Kumar, Shaji
AU  - Kumar S
FAU - Hayman, Suzanne
AU  - Hayman S
FAU - Buadi, Francis
AU  - Buadi F
FAU - Kyle, Robert A
AU  - Kyle RA
FAU - Greipp, Philip R
AU  - Greipp PR
FAU - Lust, John A
AU  - Lust JA
FAU - Russell, Stephen
AU  - Russell S
FAU - Rajkumar, S Vincent
AU  - Rajkumar SV
FAU - Fonseca, Rafael
AU  - Fonseca R
FAU - Dispenzieri, Angela
AU  - Dispenzieri A
LA  - eng
GR  - P01 CA062242/CA/NCI NIH HHS/United States
GR  - CA062242/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090211
PL  - Italy
TA  - Haematologica
JT  - Haematologica
JID - 0417435
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloidosis/*genetics/pathology/therapy
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - Female
MH  - Humans
MH  - Immunoglobulin Light Chains/genetics
MH  - In Situ Hybridization, Fluorescence/methods/statistics & numerical data
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - *Translocation, Genetic
PMC - PMC2649355
EDAT- 2009/02/13 09:00
MHDA- 2009/06/23 09:00
PMCR- 2009/03/01
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/06/23 09:00 [medline]
PHST- 2009/03/01 00:00 [pmc-release]
AID - haematol.13369 [pii]
AID - 0940380 [pii]
AID - 10.3324/haematol.13369 [doi]
PST - ppublish
SO  - Haematologica. 2009 Mar;94(3):380-6. doi: 10.3324/haematol.13369. Epub 2009 Feb 
      11.