PMID- 19211996
OWN - NLM
STAT- MEDLINE
DCOM- 20090423
LR  - 20200106
IS  - 1734-1140 (Print)
IS  - 1734-1140 (Linking)
VI  - 60
IP  - 6
DP  - 2008 Nov-Dec
TI  - Expression of brain-derived neurotrophic factor is not modulated by chronic mild 
      stress in the rat hippocampus and amygdala.
PG  - 1001-7
AB  - Accumulating evidence supports a role for brain-derived neurotrophic factor 
      (BDNF) in depression. However, most of these studies have been performed in 
      animal models that have a low face validity with regard to the human disease. 
      Here, we examined the regulation of BDNF expression in the hippocampus and 
      amygdala of rats subjected to the chronic mild stress (CMS) model of depression, 
      a paradigm that induces anhedonia, a core symptom of depression. We found that 
      exposure of rats to the CMS paradigm did not modulate BDNF mRNA expression in the 
      hippocampus and amygdala. In addition, chronic administration of imipramine, 
      which reversed CMS-induced anhedonia, did not alter BDNF mRNA expression in these 
      limbic structures.
FAU - Allaman, Igor
AU  - Allaman I
AD  - Laboratory of Neuroenergetics and Cellular Dynamics, Brain Mind Institute, Ecole 
      Polytechnique Federale de Lausanne, Lausanne (EPFL), CH-1015, Switzerland.
FAU - Papp, Mariusz
AU  - Papp M
FAU - Kraftsik, Rudolf
AU  - Kraftsik R
FAU - Fiumelli, Hubert
AU  - Fiumelli H
FAU - Magistretti, Pierre J
AU  - Magistretti PJ
FAU - Martin, Jean-Luc
AU  - Martin JL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Switzerland
TA  - Pharmacol Rep
JT  - Pharmacological reports : PR
JID - 101234999
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amygdala/*metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Chronic Disease
MH  - Depression/*metabolism
MH  - *Disease Models, Animal
MH  - *Gene Expression Regulation
MH  - Hippocampus/*metabolism
MH  - Male
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/metabolism
EDAT- 2009/02/13 09:00
MHDA- 2009/04/25 09:00
CRDT- 2009/02/13 09:00
PHST- 2008/08/15 00:00 [received]
PHST- 2008/11/26 00:00 [revised]
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
PST - ppublish
SO  - Pharmacol Rep. 2008 Nov-Dec;60(6):1001-7.