PMID- 19212832
OWN - NLM
STAT- MEDLINE
DCOM- 20090423
LR  - 20161125
IS  - 1532-4192 (Electronic)
IS  - 0735-7907 (Linking)
VI  - 27
IP  - 4
DP  - 2009 May
TI  - Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of 
      the MAPK cascade in human fibrosarcoma HT-1080 cells.
PG  - 384-90
LID - 10.1080/07357900802491469 [doi]
AB  - Autotaxin (ATX) is an approximately 125-kDa transmembrane protein that is 
      considered to be a tumor progression factor based on its lysophospholipase D 
      activity. Here, we report that lysophosphatidic acid produced by ATX promotes the 
      secretion of matrix metalloproteinase-3 (MMP3) from the human fibrosarcoma cell 
      line HT-1080. The c-Jun N-terminal kinases (JNKs) and c-Jun of HT-1080 cells were 
      rapidly phosphorylated after ATX treatment. A specific JNK inhibitor also 
      exhibited this activation of signaling molecules and MMP3 expression. The present 
      results suggest a novel function of ATX in promoting MMP3 production via the 
      mitogen-activated protein kinase cascade, thereby stimulating tumor cell 
      invasiveness.
FAU - Haga, Arayo
AU  - Haga A
AD  - Gifu Prefectural Research Institute for Health and Environmental Science, 
      Naka-Fudougaoka, Kakamigahara, Japan. haga-arayo@pref.gifu.lg.jp
FAU - Nagai, Hiroyuki
AU  - Nagai H
FAU - Deyashiki, Yoshihiro
AU  - Deyashiki Y
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cancer Invest
JT  - Cancer investigation
JID - 8307154
RN  - 0 (Lysophospholipids)
RN  - 0 (Multienzyme Complexes)
RN  - 0 (Protein Kinase Inhibitors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 3.1.4.- (Phosphoric Diester Hydrolases)
RN  - EC 3.1.4.1 (Phosphodiesterase I)
RN  - EC 3.1.4.39 (alkylglycerophosphoethanolamine phosphodiesterase)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.6.1.- (Pyrophosphatases)
RN  - PG6M3969SG (lysophosphatidic acid)
SB  - IM
MH  - Cell Line, Tumor
MH  - Fibrosarcoma/*enzymology/pathology
MH  - Humans
MH  - JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors/*metabolism
MH  - Lysophospholipids/metabolism
MH  - *MAP Kinase Signaling System/drug effects
MH  - Matrix Metalloproteinase 3/genetics/*metabolism
MH  - Multienzyme Complexes/*metabolism
MH  - Neoplasm Invasiveness
MH  - Phosphodiesterase I/*metabolism
MH  - Phosphoric Diester Hydrolases
MH  - Phosphorylation
MH  - Protein Kinase Inhibitors/pharmacology
MH  - Pyrophosphatases/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Recombinant Proteins/metabolism
MH  - Up-Regulation
EDAT- 2009/02/13 09:00
MHDA- 2009/04/25 09:00
CRDT- 2009/02/13 09:00
PHST- 2009/02/13 09:00 [entrez]
PHST- 2009/02/13 09:00 [pubmed]
PHST- 2009/04/25 09:00 [medline]
AID - 908650320 [pii]
AID - 10.1080/07357900802491469 [doi]
PST - ppublish
SO  - Cancer Invest. 2009 May;27(4):384-90. doi: 10.1080/07357900802491469.