PMID- 19215378
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20090213
IS  - 0953-8194 (Print)
IS  - 0953-8194 (Linking)
VI  - 2
IP  - 4
DP  - 1990 Aug 1
TI  - Effects of cysteamine pretreatment and hypothalamic periventricular nucleus 
      lesion on the cold-stimulated thyrotropin responses to intracerebroventricular 
      5-hydroxytryptamine in male rats.
PG  - 485-92
LID - 10.1111/j.1365-2826.1990.tb00437.x [doi]
AB  - Abstract The hypothalamic somatostatinergic system was devitalized in male rats 
      by intracerebroventricular (icv) cysteamine (CSH) pretreatment (250 mug/rat/day 
      into the third ventricle) on 4 consecutive days or by a limited lesion of the 
      hypothalamic periventricular nucleus (PeVNx). The acute effect of icv serotonin 
      (5-HT) on the cold-stimulated thyrotropin (TSH) and prolactin responses were 
      studied in these animals. The experiments were performed 24 h after the last 
      saline or CSH infusions and 7 days after the sham- or PeVN-lesions. CSH and PeVNx 
      decreased the hypothalamic somatostatin content by 44% to 57% and 19% to 28%, 
      respectively. PeVNx did not affect hypothalamic thyrotropin-releasing hormone 
      content. 5-HT infusion (9 mug/rat icv) into the anterior third ventricle 
      elevated, although not significantly, TSH levels in both saline- or 
      CSH-pretreated rats. 5-HT infusion into the anterior third ventricle did not 
      affect TSH in sham-operated rats. However, 5-HT augmented the cold-stimulated TSH 
      levels after PeVNx compared to sham-lesion. Inversely, 5-HT infusion (9 mug/rat) 
      into the posterior third ventricle inhibited TSH secretion irrespective of the 
      pretreatment or lesion. The inhibitory action of 5-HT on TSH was significantly 
      suppressed by CSH. 5-HT infusions elevated serum prolactin levels irrespective of 
      the infusion site, pretreatment or lesion. 5-HT infusion into both the anterior 
      and the posterior third ventricle decreased rectal temperature in 
      saline-pretreated, sham- and PeVN-lesioned rats. The hypothermie effect of 5-HT 
      was weakened by CSH. The hypothalamic levels of noradrenaline, dopamine and their 
      metabolites were not significantly affected by CSH and PeVNx. 5-HT infusion into 
      the anterior third ventricle decreased hypothalamic dopamine content in both 
      saline- and CSH-pretreated rats. However, such an effect was not seen in sham- or 
      PeVN-lesioned animals. Although CSH is an inhibitor of dopamine-beta-hydroxylase, 
      this activity was not reflected in serum TSH or prolactin levels. The results 
      support our hypothesis of the site-dependent action of icv 5-HT or TSH secretion. 
      The elevation of TSH levels may arise from the inhibition of somatostatin release 
      from rostral anterior hypothalamus. The inhibition of TSH secretion may result 
      from the inhibition of thyrotropin-releasing hormone release from more caudal 
      periventricular structures of the hypothalamus.
FAU - Toivonent, M
AU  - Toivonent M
AD  - Research Unit of Neurobiology, University of Helsinki, Finland.
FAU - Tuomainen, P
AU  - Tuomainen P
FAU - Rauhala, P
AU  - Rauhala P
FAU - Mannisto, P T
AU  - Mannisto PT
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Neuroendocrinol
JT  - Journal of neuroendocrinology
JID - 8913461
EDAT- 1990/08/01 00:00
MHDA- 1990/08/01 00:01
CRDT- 2009/02/14 09:00
PHST- 2009/02/14 09:00 [entrez]
PHST- 1990/08/01 00:00 [pubmed]
PHST- 1990/08/01 00:01 [medline]
AID - JNE485 [pii]
AID - 10.1111/j.1365-2826.1990.tb00437.x [doi]
PST - ppublish
SO  - J Neuroendocrinol. 1990 Aug 1;2(4):485-92. doi: 
      10.1111/j.1365-2826.1990.tb00437.x.