PMID- 19215635
OWN - NLM
STAT- MEDLINE
DCOM- 20091020
LR  - 20220318
IS  - 1469-8978 (Electronic)
IS  - 0033-2917 (Linking)
VI  - 39
IP  - 9
DP  - 2009 Sep
TI  - Early adversity and 5-HTT/BDNF genes: new evidence of gene-environment 
      interactions on depressive symptoms in a general population.
PG  - 1425-32
LID - 10.1017/S0033291709005248 [doi]
AB  - BACKGROUND: Adverse childhood experiences have been described as one of the major 
      environmental risk factors for depressive disorder. Similarly, the deleterious 
      impact of early traumatic experiences on depression seems to be moderated by 
      individual genetic variability. Serotonin transporter (5-HTT) and brain-derived 
      neurotrophic factor (BDNF) modulate the effect of childhood adversity on adult 
      depression, although inconsistencies across studies have been found. Moreover, 
      the gene x environment (GxE) interaction concerning the different types of 
      childhood adversity remains poorly understood. The aim of this study was to 
      analyse the putative interaction between the 5-HTT gene (5-HTTLPR polymorphism), 
      the BDNF gene (Val66Met polymorphism) and childhood adversity in accounting for 
      adult depressive symptoms. METHOD: A sample of 534 healthy individuals filled in 
      self-report questionnaires of depressive symptomatology [the Symptom Check List 
      90 Revised (SCL-90-R)] and different types of childhood adversities [the 
      Childhood Trauma Questionnaire (CTQ)]. The 5-HTTLPR polymorphism (5-HTT gene) and 
      the Val66Met polymorphism (BDNF gene) were genotyped in the whole sample. 
      RESULTS: Total childhood adversity (beta=0.27, p<0.001), childhood sexual abuse 
      (CSA; beta=0.17, p<0.001), childhood emotional abuse (beta=0.27, p<0.001) and 
      childhood emotional neglect (beta=0.22, p<0.001) had an impact on adult 
      depressive symptoms. CSA had a greater impact on depressive symptoms in Met 
      allele carriers of the BDNF gene than in the Val/Val group (F=5.87, p<0.0001), 
      and in S carriers of the 5-HTTLPR polymorphism (5-HTT gene) (F=5.80, p<0.0001). 
      CONCLUSIONS: Childhood adversity per se predicted higher levels of adult 
      depressive symptoms. In addition, BDNF Val66Met and 5-HTTLPR polymorphisms seemed 
      to moderate the effect of CSA on adult depressive symptoms.
FAU - Aguilera, M
AU  - Aguilera M
AD  - Unitat d'Antropologia, Departament Biologia Animal, Facultat de Biologia, 
      Universitat de Barcelona and CIBER de Salud Mental, Instituto de Salud Carlos 
      III, Spain.
FAU - Arias, B
AU  - Arias B
FAU - Wichers, M
AU  - Wichers M
FAU - Barrantes-Vidal, N
AU  - Barrantes-Vidal N
FAU - Moya, J
AU  - Moya J
FAU - Villa, H
AU  - Villa H
FAU - van Os, J
AU  - van Os J
FAU - Ibanez, M I
AU  - Ibanez MI
FAU - Ruiperez, M A
AU  - Ruiperez MA
FAU - Ortet, G
AU  - Ortet G
FAU - Fananas, L
AU  - Fananas L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090212
PL  - England
TA  - Psychol Med
JT  - Psychological medicine
JID - 1254142
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (SLC6A4 protein, human)
RN  - 0 (Serotonin Plasma Membrane Transport Proteins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Alleles
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Child
MH  - Child Abuse/psychology
MH  - Depressive Disorder/*genetics/psychology
MH  - Epistasis, Genetic/*genetics
MH  - Female
MH  - Gene Expression Regulation/physiology
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - *Life Change Events
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Serotonin Plasma Membrane Transport Proteins/*genetics
MH  - *Social Environment
EDAT- 2009/02/14 09:00
MHDA- 2009/10/21 06:00
CRDT- 2009/02/14 09:00
PHST- 2009/02/14 09:00 [entrez]
PHST- 2009/02/14 09:00 [pubmed]
PHST- 2009/10/21 06:00 [medline]
AID - S0033291709005248 [pii]
AID - 10.1017/S0033291709005248 [doi]
PST - ppublish
SO  - Psychol Med. 2009 Sep;39(9):1425-32. doi: 10.1017/S0033291709005248. Epub 2009 
      Feb 12.