PMID- 19217650
OWN - NLM
STAT- MEDLINE
DCOM- 20101109
LR  - 20110223
IS  - 1532-866X (Electronic)
IS  - 0049-0172 (Linking)
VI  - 40
IP  - 1
DP  - 2010 Aug
TI  - Is remitting seronegative symmetrical synovitis with pitting edema (RS3PE) a 
      subset of rheumatoid arthritis?
PG  - 89-94
LID - 10.1016/j.semarthrit.2008.11.006 [doi]
AB  - OBJECTIVES: To contrast and compare the spectrum of remitting seronegative 
      symmetrical synovitis with pitting edema (RS3PE) with rheumatoid arthritis (RA) 
      using an illustrative case. METHODS: The relevant English literature of RS3PE was 
      searched using the keywords "RS3PE" alone and in combination with terms such as 
      neoplasia and rheumatic disease. Original and review articles were reviewed and 
      the clinical setting was exemplified with a case report. RESULTS: RS3PE initially 
      was reported to represent a form of RA. However, RS3PE has clinical features that 
      are different from both early- and late-onset RA, such as lack of bony erosions 
      and rheumatoid factor. RS3PE is thought to involve vascular endothelial growth 
      factor, suggesting an infectious etiology, generally has an excellent prognosis, 
      and is associated with neoplasia not commonly seen in RA, and the RA associated 
      human leukocyte antigen (HLA) DRB1 genotype is absent. CONCLUSIONS: Based on the 
      clinical, laboratory, suspected infectious etiology, genetic differences, and 
      types of associated malignancies, RS3PE appears to be a distinct entity rather 
      than a subset of RA.
CI  - Copyright 2010 Elsevier Inc. All rights reserved.
FAU - Yao, Qingping
AU  - Yao Q
AD  - Division of Rheumatology and Immunology, Department of Medicine, David Geffen 
      Medical School at UCLA, Los Angeles, CA 90095, USA.
FAU - Su, Xiangqian
AU  - Su X
FAU - Altman, Roy D
AU  - Altman RD
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20090213
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
CIN - Semin Arthritis Rheum. 2011 Feb;40(4):e1. PMID: 21272737
MH  - Arthritis, Rheumatoid/*complications/diagnosis
MH  - Diagnosis, Differential
MH  - *Edema/diagnosis/etiology/immunology
MH  - Humans
MH  - Paraneoplastic Syndromes
MH  - Recurrence
MH  - Serologic Tests
MH  - *Synovitis/diagnosis/etiology/immunology
MH  - Vascular Endothelial Growth Factor A/*immunology
EDAT- 2009/02/17 09:00
MHDA- 2010/11/10 06:00
CRDT- 2009/02/17 09:00
PHST- 2008/08/26 00:00 [received]
PHST- 2008/11/08 00:00 [revised]
PHST- 2008/11/24 00:00 [accepted]
PHST- 2009/02/17 09:00 [entrez]
PHST- 2009/02/17 09:00 [pubmed]
PHST- 2010/11/10 06:00 [medline]
AID - S0049-0172(08)00214-X [pii]
AID - 10.1016/j.semarthrit.2008.11.006 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2010 Aug;40(1):89-94. doi: 
      10.1016/j.semarthrit.2008.11.006. Epub 2009 Feb 13.