PMID- 19217756 OWN - NLM STAT- MEDLINE DCOM- 20090605 LR - 20131121 IS - 1873-7862 (Electronic) IS - 0924-977X (Linking) VI - 19 IP - 5 DP - 2009 May TI - Genetic study of BDNF, DRD3, and their interaction in tardive dyskinesia. PG - 317-28 LID - 10.1016/j.euroneuro.2009.01.001 [doi] AB - Tardive dyskinesia (TD) is a neuroleptic-induced movement disorder. Its pathophysiology is unclear. The most consistent genetic findings have shown an association with the Ser9Gly polymorphism of the DRD3 gene. However, only few polymorphisms within DRD3 has been tested, and a comprehensive examination of DRD3 in TD is still lacking. Further, brain-derived neurotrophic factor (BDNF), a neuronal growth and survival peptide, regulates DRD3 expression and may be involved in the neuronal degeneration observed in TD. In the present study, we investigated 15 tag DRD3 polymorphisms and four tag BDNF polymorphisms for association with TD in our sample of Caucasian schizophrenia patients (N=171). While BDNF markers showed no association, a haplotype containing rs3732782, rs905568, and rs7620754 in the 5' region of DRD3 was associated with TD diagnosis (p[10,000 permutations]=0.007). We also found evidence of interaction between BDNF and DRD3 polymorphisms. Further studies are needed to confirm these findings. FAU - Zai, Clement C AU - Zai CC AD - Centre for Addiction and Mental Health, Toronto, Ontario, Canada. FAU - Tiwari, Arun K AU - Tiwari AK FAU - De Luca, Vincenzo AU - De Luca V FAU - Muller, Daniel J AU - Muller DJ FAU - Bulgin, Natalie AU - Bulgin N FAU - Hwang, Rudi AU - Hwang R FAU - Zai, Gwyneth C AU - Zai GC FAU - King, Nicole AU - King N FAU - Voineskos, Aristotle N AU - Voineskos AN FAU - Meltzer, Herbert Y AU - Meltzer HY FAU - Lieberman, Jeffrey A AU - Lieberman JA FAU - Potkin, Steven G AU - Potkin SG FAU - Remington, Gary AU - Remington G FAU - Kennedy, James L AU - Kennedy JL LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20090213 PL - Netherlands TA - Eur Neuropsychopharmacol JT - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JID - 9111390 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Receptors, Dopamine D3) RN - 452VLY9402 (Serine) RN - TE7660XO1C (Glycine) SB - IM MH - Adult MH - Akathisia, Drug-Induced/etiology/*genetics MH - Analysis of Variance MH - Brain-Derived Neurotrophic Factor/*genetics MH - Chi-Square Distribution MH - Female MH - Gene Frequency MH - *Genetic Predisposition to Disease MH - Genotype MH - Glycine/genetics MH - Humans MH - Male MH - Middle Aged MH - Polymorphism, Genetic/*genetics MH - Receptors, Dopamine D3/*genetics MH - Schizophrenia/complications MH - Serine/genetics MH - Young Adult EDAT- 2009/02/17 09:00 MHDA- 2009/06/06 09:00 CRDT- 2009/02/17 09:00 PHST- 2008/08/13 00:00 [received] PHST- 2009/01/05 00:00 [revised] PHST- 2009/01/08 00:00 [accepted] PHST- 2009/02/17 09:00 [entrez] PHST- 2009/02/17 09:00 [pubmed] PHST- 2009/06/06 09:00 [medline] AID - S0924-977X(09)00008-X [pii] AID - 10.1016/j.euroneuro.2009.01.001 [doi] PST - ppublish SO - Eur Neuropsychopharmacol. 2009 May;19(5):317-28. doi: 10.1016/j.euroneuro.2009.01.001. Epub 2009 Feb 13.