PMID- 19218138
OWN - NLM
STAT- MEDLINE
DCOM- 20100429
LR  - 20131121
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 29
IP  - 1
DP  - 2009 Jan
TI  - [Effects of phosphocreatine on plasma brain natriuretic peptide level in elderly 
      patients with chronic congestive heart failure].
PG  - 154-5, 159
AB  - OBJECTIVE: To investigate the therapeutic effects of phosphocreatine in elderly 
      patients with chronic congestive heart failure (CHF) and its effects on plasma 
      brain natriuretic peptide (BNP). METHODS: Forty elderly patients with chronic CHF 
      were randomly divided into two groups to receive basic treatment (control group) 
      and additional phosphocreatine treatment (treatment group) with a treatment 
      course of 8 weeks. The patients were evaluated for improvement in New York Heart 
      Association (NYHA) functional class, symptoms, left ventricular end-diastolic 
      diameter (LVEDD), left ventricular end-systolic diameter (LVESD), and left 
      ventricular ejection fraction (LVEF) and the levels of BNP before and after 
      treatment. RESULTS: After 8 weeks of treatment, the overall efficacy rate was 
      significantly higher in treatment group than in the control group, and LVESD, 
      LVEDD, LVEF and BNP level of the treatment group were significantly lowered in 
      comparison with those of the control group (P<0.05). CONCLUSION: Phosphocreatine 
      in addition to the basic treatment can reduce the BNP level and improve the 
      cardiac systolic and diastolic function in elderly patients with chronic CHF.
FAU - Du, Xiao-hong
AU  - Du XH
AD  - Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000, China. 
      dxh@hosp1.ac.cn
FAU - Liang, Fei-yu
AU  - Liang FY
FAU - Zhao, Xiao-wei
AU  - Zhao XW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Cardiotonic Agents)
RN  - 020IUV4N33 (Phosphocreatine)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cardiotonic Agents/therapeutic use
MH  - Female
MH  - Heart Failure/*blood/*drug therapy
MH  - Humans
MH  - Male
MH  - Natriuretic Peptide, Brain/*blood
MH  - Phosphocreatine/*therapeutic use
MH  - Ventricular Dysfunction, Left/physiopathology
EDAT- 2009/02/17 09:00
MHDA- 2010/04/30 06:00
CRDT- 2009/02/17 09:00
PHST- 2009/02/17 09:00 [entrez]
PHST- 2009/02/17 09:00 [pubmed]
PHST- 2010/04/30 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2009 Jan;29(1):154-5, 159.