PMID- 19219303
OWN - NLM
STAT- MEDLINE
DCOM- 20091008
LR  - 20190606
IS  - 1414-431X (Electronic)
IS  - 0100-879X (Linking)
VI  - 42
IP  - 1
DP  - 2009 Jan
TI  - Antidipsogenic effects of central adenosine-5'-triphosphate.
PG  - 105-13
LID - S0100-879X2009000100015 [pii]
AB  - Besides other physiological functions, adenosine-5'-triphosphate (ATP) is also a 
      neurotransmitter that acts on purinergic receptors. In spite of the presence of 
      purinergic receptors in forebrain areas involved with fluid-electrolyte balance, 
      the effect of ATP on water intake has not been investigated. Therefore, we 
      studied the effects of intracerebroventricular (icv) injections of ATP (100, 200 
      and 300 nmol/microL) alone or combined with DPCPX or PPADS (P1 and P2 purinergic 
      antagonists, respectively, 25 nmol/microL) on water intake induced by water 
      deprivation. In addition, the effect of icv ATP was also tested on water intake 
      induced by intragastric load of 12% NaCl (2 mL/rat), acute treatment with the 
      diuretic/natriuretic furosemide (20 mg/kg), icv angiotensin II (50 ng/microL) or 
      icv carbachol (a cholinergic agonist, 4 nmol/microL), on sodium depletion-induced 
      1.8% NaCl intake, and on food intake induced by food deprivation. Male Holtzman 
      rats (280-320 g, N = 7-11) had cannulas implanted into the lateral ventricle. Icv 
      ATP (300 nmol/microL) reduced water intake induced by water deprivation (13.1 +/- 
      1.9 vs saline: 19.0 +/- 1.4 mL/2 h; P < 0.05), an effect blocked by pre-treatment 
      with PPADS, but not DPCPX. Icv ATP also reduced water intake induced by NaCl 
      intragastric load (5.6 +/- 0.9 vs saline: 10.3 +/- 1.4 mL/2 h; P < 0.05), acute 
      furosemide treatment (0.5 +/- 0.2 vs saline: 2.3 +/- 0.6 mL/15 min; P < 0.05), 
      and icv angiotensin II (2.2 +/- 0.8 vs saline: 10.4 +/- 2.0 mL/2 h; P < 0.05), 
      without changing icv carbachol-induced water intake, sodium depletion-induced 
      1.8% NaCl intake and food deprivation-induced food intake. These data suggest 
      that central ATP, acting on purinergic P2 receptors, reduces water intake induced 
      by intracellular and extracellular dehydration.
FAU - de Faria, D R G
AU  - de Faria DR
AD  - Departamento de Fisiologia e Patologia, Faculdade de Odontologia de Araraquara, 
      Universidade Estadual Paulista, Araraquara, SP, Brazil.
FAU - Santana, J S
AU  - Santana JS
FAU - Menani, J V
AU  - Menani JV
FAU - de Paula, P M
AU  - de Paula PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Brazil
TA  - Braz J Med Biol Res
JT  - Brazilian journal of medical and biological research = Revista brasileira de 
      pesquisas medicas e biologicas
JID - 8112917
RN  - 0 (Purinergic P1 Receptor Agonists)
RN  - 0 (Purinergic P1 Receptor Antagonists)
RN  - 0 (Purinergic P2 Receptor Agonists)
RN  - 0 (Purinergic P2 Receptor Antagonists)
RN  - 0 (Xanthines)
RN  - 149017-66-3 (pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid)
RN  - 5V5IOJ8338 (Pyridoxal Phosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - 9PTP4FOI9E (1,3-dipropyl-8-cyclopentylxanthine)
SB  - IM
MH  - Adenosine Triphosphate/*administration & dosage/pharmacology
MH  - Animals
MH  - Drinking/*drug effects/physiology
MH  - Eating/drug effects/physiology
MH  - Injections, Intraventricular
MH  - Male
MH  - Purinergic P1 Receptor Agonists
MH  - Purinergic P1 Receptor Antagonists
MH  - Purinergic P2 Receptor Agonists
MH  - Purinergic P2 Receptor Antagonists
MH  - Pyridoxal Phosphate/administration & dosage/*analogs & derivatives/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Water Deprivation/*physiology
MH  - Xanthines/*administration & dosage/pharmacology
EDAT- 2009/02/17 09:00
MHDA- 2009/10/09 06:00
CRDT- 2009/02/17 09:00
PHST- 2008/09/13 00:00 [received]
PHST- 2009/01/20 00:00 [accepted]
PHST- 2009/02/17 09:00 [entrez]
PHST- 2009/02/17 09:00 [pubmed]
PHST- 2009/10/09 06:00 [medline]
AID - S0100-879X2009000100015 [pii]
AID - 10.1590/s0100-879x2009000100015 [doi]
PST - ppublish
SO  - Braz J Med Biol Res. 2009 Jan;42(1):105-13. doi: 10.1590/s0100-879x2009000100015.