PMID- 19219407
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20220419
IS  - 1559-0259 (Electronic)
IS  - 1530-7905 (Linking)
VI  - 9
IP  - 1
DP  - 2009 Mar
TI  - Acute myocardial infarction following oral methyl-ergometrine intake.
PG  - 46-8
LID - 10.1007/s12012-009-9031-9 [doi]
AB  - Ergot derivatives are frequently administrated during cesarean delivery, induced 
      abortion, or post-partum hemorrhage to promote uterine contractions. Ergot 
      derivatives may also induce coronary spasm and intravenous ergonovine is used in 
      cardiac catheterization laboratories as a diagnostic agent. Serious ischemic 
      cardiac events related to ergonovine are rare and have most often been described 
      after intravenous use. We report the case of a 38-year-old woman with a ST 
      elevation myocardial infarction (STEMI) few days after artificially induced 
      abortion by oral prescription of methylergometrine. Coronary angiography 
      performed 2 days after onset of chest pain did not reveal any abnormalities of 
      the coronary arteries but a provocative test using intravenous methylergometrine 
      was positive with reproduction of chest pain, ECG changes and with a significant 
      narrowing localized on the second segment of the left anterior descending artery 
      at the angiogram. Thus, since methylergometrin may clearly induce coronary spasm 
      when prescribed orally, chest pain occurring under oral treatment should require 
      immediate attention even if atypical or in the absence of cardiovascular risk 
      factors.
FAU - de Labriolle, Axel
AU  - de Labriolle A
AD  - Service de Cardiologie, Pole Coeur Thorax Vasculaire Hemostase, Centre 
      Hospitalier Universitaire Trousseau, 37044, Tours, France. 
      a.delabriolle@chu-tours.fr
FAU - Genee, Olivier
AU  - Genee O
FAU - Heggs, Laurens Mitchell
AU  - Heggs LM
FAU - Fauchier, Laurent
AU  - Fauchier L
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090214
PL  - United States
TA  - Cardiovasc Toxicol
JT  - Cardiovascular toxicology
JID - 101135818
RN  - 0 (Abortifacient Agents)
RN  - 0 (Oxytocics)
RN  - 0 (Vasodilator Agents)
RN  - W53L6FE61V (Methylergonovine)
SB  - IM
MH  - Abortifacient Agents/administration & dosage/*adverse effects
MH  - Administration, Oral
MH  - Adult
MH  - Angina Pectoris/chemically induced
MH  - Coronary Angiography
MH  - Coronary Vasospasm/*chemically induced/diagnosis/drug therapy
MH  - Drug Therapy, Combination
MH  - Electrocardiography
MH  - Female
MH  - Humans
MH  - Methylergonovine/administration & dosage/*adverse effects
MH  - Myocardial Infarction/*chemically induced/diagnosis/drug therapy
MH  - Oxytocics/administration & dosage/*adverse effects
MH  - Vasodilator Agents/therapeutic use
EDAT- 2009/02/17 09:00
MHDA- 2009/06/12 09:00
CRDT- 2009/02/17 09:00
PHST- 2009/01/12 00:00 [received]
PHST- 2009/01/29 00:00 [accepted]
PHST- 2009/02/17 09:00 [entrez]
PHST- 2009/02/17 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
AID - 10.1007/s12012-009-9031-9 [doi]
PST - ppublish
SO  - Cardiovasc Toxicol. 2009 Mar;9(1):46-8. doi: 10.1007/s12012-009-9031-9. Epub 2009 
      Feb 14.