PMID- 19219527
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20211020
IS  - 1661-4917 (Electronic)
IS  - 0004-069X (Print)
IS  - 0004-069X (Linking)
VI  - 57
IP  - 1
DP  - 2009 Jan-Feb
TI  - Virulence factor genotypes of Helicobacter pylori affect cure rates of 
      eradication therapy.
PG  - 45-56
LID - 10.1007/s00005-009-0007-z [doi]
AB  - The cure rates of Helicobacter pylori infection by using a combination of a 
      proton pump inhibitor (PPI) and antimicrobial agents are mainly influenced by 
      bacterial susceptibility to antimicrobial agents and the magnitude of acid 
      inhibition during the treatment. Currently used empirical triple therapies do not 
      reliably produce a > or =80% cure rate on an intention-to-treat basis. Therefore, 
      tailored regimens based on relevant microbiological findings and pharmacogenomics 
      are recommended for attaining an acceptable > or =95% cure rate. Recently, 
      virulence factors of H. pylori, such as cagA and vacA, are reported to be major 
      factors determining the cure rates. Individuals infected with strains with 
      cagA-negative and vacA s2 genotypes have significantly increased risk of 
      eradication failure of H. pylori infection. These virulence factors enhance 
      gastric mucosal inflammation and are associated with the development of peptic 
      ulcer and gastric cancer. H. pylori virulence factors induce proinflammatory 
      cytokines, such as interleukin (IL)-1, IL-8, and tumor necrosis factor (TNF)- 
      which influence mucosal inflammation and/or gastric acid secretion. When 
      physicians select an H. pylori eradication regimen with an acceptable cure rate, 
      they might need to consider H. pylori virulence factors, especially cagA and 
      vacA.
FAU - Sugimoto, Mitsushige
AU  - Sugimoto M
AD  - Department of Medicine, Michael E. DeBakey Veterans Affairs Medical Center and 
      Baylor College of Medicine, Houston, TX, USA.
FAU - Yamaoka, Yoshio
AU  - Yamaoka Y
LA  - eng
GR  - R01 DK062813/DK/NIDDK NIH HHS/United States
GR  - R01 DK062813-05/DK/NIDDK NIH HHS/United States
GR  - R01 DK62813/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20090214
PL  - Poland
TA  - Arch Immunol Ther Exp (Warsz)
JT  - Archivum immunologiae et therapiae experimentalis
JID - 0114365
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Proteins)
RN  - 0 (Cytokines)
RN  - 0 (Histamine H2 Antagonists)
RN  - 0 (VacA protein, Helicobacter pylori)
RN  - 0 (cagA protein, Helicobacter pylori)
SB  - IM
MH  - Anti-Bacterial Agents/administration & dosage/pharmacokinetics/therapeutic use
MH  - Anti-Ulcer Agents/administration & dosage/therapeutic use
MH  - Antigens, Bacterial/genetics/physiology
MH  - Bacterial Proteins/genetics/physiology
MH  - Cytokines/biosynthesis/genetics
MH  - Drug Resistance, Multiple, Bacterial
MH  - Drug Therapy, Combination
MH  - Gastric Acid/metabolism
MH  - Gastritis/complications/drug therapy/*microbiology
MH  - Genomic Islands/genetics
MH  - Genotype
MH  - Helicobacter Infections/complications/drug therapy/*microbiology
MH  - Helicobacter pylori/drug effects/genetics/isolation & purification/*pathogenicity
MH  - Histamine H2 Antagonists/administration & dosage/therapeutic use
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - Remission Induction
MH  - Stomach Neoplasms/etiology/microbiology
MH  - Stomach Ulcer/etiology/microbiology
MH  - Virulence/genetics
PMC - PMC3118989
MID - NIHMS178139
COIS- Disclosure: No conflicts of interest exist in this manuscript.
EDAT- 2009/02/17 09:00
MHDA- 2009/04/03 09:00
PMCR- 2011/06/21
CRDT- 2009/02/17 09:00
PHST- 2008/07/07 00:00 [received]
PHST- 2008/10/20 00:00 [accepted]
PHST- 2009/02/17 09:00 [entrez]
PHST- 2009/02/17 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2011/06/21 00:00 [pmc-release]
AID - 10.1007/s00005-009-0007-z [doi]
PST - ppublish
SO  - Arch Immunol Ther Exp (Warsz). 2009 Jan-Feb;57(1):45-56. doi: 
      10.1007/s00005-009-0007-z. Epub 2009 Feb 14.