PMID- 19220211
OWN - NLM
STAT- MEDLINE
DCOM- 20091130
LR  - 20090727
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 7
DP  - 2009 Jul
TI  - Food allergy and food sensitization in early childhood: results from the DARC 
      cohort.
PG  - 1023-9
LID - 10.1111/j.1398-9995.2009.01952.x [doi]
AB  - BACKGROUND: The prevalence of food hypersensitivity (FHS) and the relationship 
      with atopic dermatitis (AD) is controversial. The aim of this study was to 
      determine the development of FHS and to correlate this with AD in relation to 
      sensitization and symptoms. METHODS: This study combines new data from birth to 
      18 months of age with previous published results from 3 and 6 years. The Danish 
      Allergy Research Centre cohort, including 562 children, is a unique, 
      population-based, prospective birth cohort, with clinical examinations at all 
      follow-ups. All children were examined for the development of AD using 
      Hanifin-Rajka criteria and for FHS using interviews, skin prick test (SPT), 
      specific immunoglobulin E (IgE), and food challenge according to EAACI 
      guidelines. RESULTS: Twenty children were confirmed with FHS to milk, egg, and 
      peanut. FHS peaked at 18 months (3.6%) and then decreased to 1.2% at 72 months of 
      age. No new cases were found after 3 years. Self-reporting could only be 
      confirmed in 31% of cases. Among the 122 children with AD, 18 had FHS (14.8%). 
      FHS was IgE-mediated in 95% of the cases but 16 of 20 children were additionally 
      sensitized to other foods which they tolerated. Children with AD were neither 
      more IgE-sensitized nor had higher levels of IgE when compared with healthy 
      children but they were more persistently sensitized. CONCLUSIONS: Sensitization 
      to foods in young children without food allergy seems to be a normal phenomenon. 
      The discrepancy between sensitization, self-reported food-related symptoms and 
      confirmed FHS illustrates the need to perform standardized oral challenges in 
      order to confirm the diagnosis of FHS.
FAU - Eller, E
AU  - Eller E
AD  - Department of Dermatology, Odense University Hospital, Odense, Denmark.
FAU - Kjaer, H F
AU  - Kjaer HF
FAU - Host, A
AU  - Host A
FAU - Andersen, K E
AU  - Andersen KE
FAU - Bindslev-Jensen, C
AU  - Bindslev-Jensen C
LA  - eng
PT  - Journal Article
DEP - 20090212
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/immunology
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Denmark/epidemiology
MH  - Dermatitis, Atopic/*epidemiology/immunology
MH  - Female
MH  - Follow-Up Studies
MH  - Food Hypersensitivity/*epidemiology/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Prospective Studies
MH  - Skin Tests
EDAT- 2009/02/18 09:00
MHDA- 2009/12/16 06:00
CRDT- 2009/02/18 09:00
PHST- 2009/02/18 09:00 [entrez]
PHST- 2009/02/18 09:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
AID - ALL1952 [pii]
AID - 10.1111/j.1398-9995.2009.01952.x [doi]
PST - ppublish
SO  - Allergy. 2009 Jul;64(7):1023-9. doi: 10.1111/j.1398-9995.2009.01952.x. Epub 2009 
      Feb 12.