PMID- 19220419
OWN - NLM
STAT- MEDLINE
DCOM- 20090518
LR  - 20211020
IS  - 1600-0609 (Electronic)
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 82
IP  - 5
DP  - 2009 May
TI  - A molecular analysis of biclonal follicular lymphoma: further evidence for bone 
      marrow origin and clonal selection.
PG  - 398-403
LID - 10.1111/j.1600-0609.2009.01233.x [doi]
AB  - We report a follicular lymphoma (FL) case presenting the coexistence of two tumor 
      cell subpopulations in lymph node (LN) and bone marrow (BM), which exhibited an 
      inverse pattern of immunoglobulin light (IgL) chain gene rearrangement and 
      expression: Igkappa-lambda+ in LN and Igkappa+lambda- in BM. These tumor clones 
      shared an identical BCL2-IgH recombination, accompanying t(14;18)(q32;q21) 
      translocation, and an identical variable, diversity and joining segments joining 
      with clone-specific VH somatic hypermutations on the untranslocated IgH allele. 
      Our study provides further evidence that FL clones, originating from common 
      progenitor cells, can be developed independently at different sites and with 
      different IgL expression after immune selection.
FAU - Nakamura, Yuichi
AU  - Nakamura Y
AD  - Department of Hematology, Saitama Medical University, Saitama, Japan. 
      ynakam@saitama-med.ac.jp
FAU - Sato, Yasutaka
AU  - Sato Y
FAU - Yoshida, Katsuhiko
AU  - Yoshida K
FAU - Kakegawa, Emi
AU  - Kakegawa E
FAU - Ito, Yoshihiro
AU  - Ito Y
FAU - Seyama, Atsushi
AU  - Seyama A
FAU - Kayano, Hidekazu
AU  - Kayano H
FAU - Bessho, Masami
AU  - Bessho M
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20090205
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
SB  - IM
MH  - Bone Marrow/*pathology
MH  - Cell Lineage
MH  - Clone Cells/pathology
MH  - Female
MH  - Genes, Immunoglobulin Light Chain
MH  - Humans
MH  - Lymphoma, Follicular/*pathology
MH  - Middle Aged
PMC - PMC2730550
EDAT- 2009/02/18 09:00
MHDA- 2009/05/19 09:00
CRDT- 2009/02/18 09:00
PHST- 2009/02/18 09:00 [entrez]
PHST- 2009/02/18 09:00 [pubmed]
PHST- 2009/05/19 09:00 [medline]
AID - EJH1233 [pii]
AID - 10.1111/j.1600-0609.2009.01233.x [doi]
PST - ppublish
SO  - Eur J Haematol. 2009 May;82(5):398-403. doi: 10.1111/j.1600-0609.2009.01233.x. 
      Epub 2009 Feb 5.