PMID- 19221964
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20131121
IS  - 1098-9048 (Electronic)
IS  - 1069-3424 (Linking)
VI  - 29
IP  - 6
DP  - 2008 Dec
TI  - Metal-induced diffuse lung disease.
PG  - 662-9
LID - 10.1055/s-0028-1101276 [doi]
AB  - The number of metals that are associated with the development of diffuse 
      parenchymal lung disease continues to expand. In addition to lung fibrosis, 
      inhalation of metal particulates can induce a wide range of lung pathology, 
      including reactive airways disease and cancer. This article focuses on diffuse 
      parenchymal diseases resulting from the inhalation of beryllium and cobalt. More 
      is known regarding the immunopathogenesis of beryllium-induced disease than is 
      known for disease induced by any other metal. Chronic beryllium disease (CBD) is 
      a granulomatous lung disorder caused by beryllium exposure in the workplace and 
      is characterized by the accumulation of beryllium-specific CD4 (+) T cells in the 
      bronchoalveolar lavage. Genetic susceptibility markers associated with increased 
      risk have been identified for both CBD and hard metal lung disease. The mechanism 
      for the genetic susceptibility of CBD lies in the ability of certain human 
      leukocyte antigen (HLA)-DP molecules to bind and present beryllium to pathogenic 
      CD4 (+) T cells. Whether the same is true for hard metal lung disease is unknown. 
      In contrast, no HLA allelic association has been identified in nickel allergic 
      subjects. The study of metal-induced lung disease allows the investigation of the 
      relationship between environmental exposure and genetic susceptibility. These 
      studies will enhance our understanding of the immunopathogenesis of metal-induced 
      disease and how exposure to these metals results in irreversible lung fibrosis.
FAU - Fontenot, Andrew P
AU  - Fontenot AP
AD  - Department of Medicine, University of Colorado Health Sciences Center, Denver, 
      Colorado 80262, USA. andrew.fontenot@uchsc.edu
FAU - Amicosante, Massimo
AU  - Amicosante M
LA  - eng
GR  - ES011810/ES/NIEHS NIH HHS/United States
GR  - HL62410,/HL/NHLBI NIH HHS/United States
GR  - M01 RR00051/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20090216
PL  - United States
TA  - Semin Respir Crit Care Med
JT  - Seminars in respiratory and critical care medicine
JID - 9431858
RN  - 0 (Alloys)
RN  - 0 (hard metal)
RN  - 3G0H8C9362 (Cobalt)
RN  - OW5102UV6N (Beryllium)
RN  - V9306CXO6G (Tungsten)
SB  - IM
MH  - Alloys/adverse effects
MH  - Berylliosis/etiology/physiopathology
MH  - Beryllium/*adverse effects
MH  - Chronic Disease
MH  - Cobalt/*adverse effects
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Inhalation Exposure/adverse effects
MH  - Lung Diseases, Interstitial/*etiology/physiopathology
MH  - Occupational Diseases/etiology/physiopathology
MH  - Occupational Exposure/adverse effects
MH  - Tungsten/adverse effects
RF  - 69
EDAT- 2009/02/18 09:00
MHDA- 2009/03/26 09:00
CRDT- 2009/02/18 09:00
PHST- 2009/02/18 09:00 [entrez]
PHST- 2009/02/18 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
AID - 10.1055/s-0028-1101276 [doi]
PST - ppublish
SO  - Semin Respir Crit Care Med. 2008 Dec;29(6):662-9. doi: 10.1055/s-0028-1101276. 
      Epub 2009 Feb 16.