PMID- 19222466
OWN - NLM
STAT- MEDLINE
DCOM- 20090624
LR  - 20090430
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 145
IP  - 3
DP  - 2009 May
TI  - HHV-6 DNA throughout the tissues of two stem cell transplant patients with 
      chromosomally integrated HHV-6 and fatal CMV pneumonitis.
PG  - 394-8
LID - 10.1111/j.1365-2141.2009.07622.x [doi]
AB  - Two patients with the characteristic high human herpesvirus 6 (HHV-6) DNA loads 
      in peripheral blood caused by chromosomally integrated (CI) virus received a 
      haematopoietic stem cell transplant (HSCT) from a donor without CI HHV-6. Both 
      patients died in consequence of cytomegalovirus (CMV) pneumonitis. At autopsy, 
      high amounts of CMV DNA were detected in lungs but at much lower levels in other 
      organs. In contrast HHV-6 DNA was detected at high levels throughout the organs 
      with the exception of donor-derived haematopoietic tissue. In individuals with 
      chromosomal integration, HHV-6 DNA is found in every tissue of recipient origin 
      indicating inheritance through the germ line.
FAU - Hubacek, Petr
AU  - Hubacek P
AD  - Department of Paediatric Haematology and Oncology, 2nd Faculty of Medicine and 
      Motol University Hospital, Charles University, Prague, The Czech Republic. 
      petr.hubacek@lfmotol.cuni.cz
FAU - Virgili, Anna
AU  - Virgili A
FAU - Ward, Katherine N
AU  - Ward KN
FAU - Pohlreich, David
AU  - Pohlreich D
FAU - Keslova, Petra
AU  - Keslova P
FAU - Goldova, Barbora
AU  - Goldova B
FAU - Markova, Marketa
AU  - Markova M
FAU - Zajac, Miroslav
AU  - Zajac M
FAU - Cinek, Ondrej
AU  - Cinek O
FAU - Nacheva, Elisabeth P
AU  - Nacheva EP
FAU - Sedlacek, Petr
AU  - Sedlacek P
FAU - Cetkovsky, Petr
AU  - Cetkovsky P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090217
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - Child
MH  - Chromosomes, Human/*virology
MH  - Cytomegalovirus/isolation & purification
MH  - Cytomegalovirus Infections/mortality
MH  - DNA, Viral/*analysis
MH  - Fatal Outcome
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Leukemia, Myeloid, Acute/mortality/therapy/virology
MH  - Lung/virology
MH  - Male
MH  - Pneumonia/mortality/virology
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/mortality/therapy/virology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Roseolovirus Infections/genetics/*virology
MH  - Virus Integration/*genetics
EDAT- 2009/02/19 09:00
MHDA- 2009/06/25 09:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2009/06/25 09:00 [medline]
AID - BJH7622 [pii]
AID - 10.1111/j.1365-2141.2009.07622.x [doi]
PST - ppublish
SO  - Br J Haematol. 2009 May;145(3):394-8. doi: 10.1111/j.1365-2141.2009.07622.x. Epub 
      2009 Feb 17.