PMID- 19222557
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20131121
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Linking)
VI  - 29
IP  - 3
DP  - 2009 Feb
TI  - Differential regulation of psychostimulant-induced gene expression of brain 
      derived neurotrophic factor and the immediate-early gene Arc in the juvenile and 
      adult brain.
PG  - 465-76
LID - 10.1111/j.1460-9568.2008.06601.x [doi]
AB  - Psychostimulant drugs are widely used in children for the treatment of 
      attention-deficit/hyperactivity disorder. Recent animal studies have suggested 
      that exposure to these agents in early life could be detrimental to brain 
      development. Here, for the first time, the effect of methylphenidate (MPH) and 
      D-amphetamine (AMPH) on the expression of two key genes for neuronal development 
      and plasticity, brain-derived neurotrophic factor (bdnf) and the effector 
      immediate early gene activity-regulated, cytoskeletal-associated protein (Arc), 
      was examined in both juvenile and adult rats. Both MPH [2 mg/kg, intraperitoneal 
      (i.p.)] and AMPH (0.5 mg/kg, i.p.) induced marked decreases of bdnf mRNA in 
      hippocampal and cortical brain regions of juveniles, whereas effects in adults 
      were significantly less (hippocampus) or opposite (frontal cortex). In 
      comparison, Arc mRNA was decreased (hippocampus and parietal cortex), largely 
      unaffected (frontal cortex) or increased (striatum) in juveniles, whereas in 
      adults, Arc mRNA increased in most brain regions. MPH-induced locomotion was also 
      measured, and showed a much smaller increase in juveniles than in adults. In 
      summary, our data show that the effects of MPH and AMPH on expression of the 
      neurodevelopmentally important genes, bdnf and Arc, differ markedly in juvenile 
      and adult rats, with juveniles showing evidence of brain region-specific 
      decreases in both genes. These age-dependent effects on gene expression may be 
      linked with the reported long-term harmful effects of psychostimulants in animal 
      models.
FAU - Banerjee, Partha S
AU  - Banerjee PS
AD  - Leicester School of Pharmacy, Faculty of Health and Life Sciences, De Montfort 
      University, The Gateway, Leicester, UK.
FAU - Aston, James
AU  - Aston J
FAU - Khundakar, Ahmad A
AU  - Khundakar AA
FAU - Zetterstrom, Tyra S C
AU  - Zetterstrom TS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Central Nervous System Stimulants)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (activity regulated cytoskeletal-associated protein)
RN  - 44RAL3456C (Methamphetamine)
RN  - CK833KGX7E (Amphetamine)
SB  - IM
MH  - Aging/genetics/metabolism
MH  - Amphetamine/pharmacology
MH  - Animals
MH  - Brain/*drug effects/growth & development/metabolism
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Central Nervous System Stimulants/*pharmacology
MH  - Cytoskeletal Proteins/*genetics
MH  - Down-Regulation/drug effects/genetics
MH  - Gene Expression Regulation/*drug effects/genetics
MH  - Genes, Immediate-Early/*drug effects/genetics
MH  - Male
MH  - Methamphetamine/pharmacology
MH  - Nerve Tissue Proteins/*genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2009/02/19 09:00
MHDA- 2009/06/13 09:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
AID - EJN6601 [pii]
AID - 10.1111/j.1460-9568.2008.06601.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2009 Feb;29(3):465-76. doi: 10.1111/j.1460-9568.2008.06601.x.