PMID- 19222991
OWN - NLM
STAT- MEDLINE
DCOM- 20090416
LR  - 20091119
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 381
IP  - 3
DP  - 2009 Apr 10
TI  - Early exercise in spinal cord injured rats induces allodynia through TrkB 
      signaling.
PG  - 339-44
LID - 10.1016/j.bbrc.2009.02.043 [doi]
AB  - Rehabilitation is important for the functional recovery of patients with spinal 
      cord injury. However, neurological events associated with rehabilitation remain 
      unclear. Herein, we investigated neuronal regeneration and exercise following 
      spinal cord injury, and found that assisted stepping exercise of spinal cord 
      injured rats in the inflammatory phase causes allodynia. Sprague-Dawley rats with 
      thoracic spinal cord contusion injury were subjected to assisted stepping 
      exercise 7 days following injury. Exercise promoted microscopic recovery of 
      corticospinal tract neurons, but the paw withdrawal threshold decreased and 
      C-fibers had aberrantly sprouted, suggesting a potential cause of the allodynia. 
      Tropomyosin-related kinase B (TrkB) receptor for brain-derived neurotrophic 
      factor (BDNF) was expressed on aberrantly sprouted C-fibers. Blocking of 
      BDNF-TrkB signaling markedly suppressed aberrant sprouting and decreased the paw 
      withdrawal threshold. Thus, early rehabilitation for spinal cord injury may cause 
      allodynia with aberrant sprouting of C-fibers through BDNF-TrkB signaling.
FAU - Endo, Teruaki
AU  - Endo T
AD  - Department of Orthopedic Surgery, Jichi Medical University, Shimotsuke, Tochigi 
      329-0498, Japan.
FAU - Ajiki, Takashi
AU  - Ajiki T
FAU - Inoue, Hirokazu
AU  - Inoue H
FAU - Kikuchi, Motoshi
AU  - Kikuchi M
FAU - Yashiro, Takashi
AU  - Yashiro T
FAU - Nakama, Sueo
AU  - Nakama S
FAU - Hoshino, Yuichi
AU  - Hoshino Y
FAU - Murakami, Takashi
AU  - Murakami T
FAU - Kobayashi, Eiji
AU  - Kobayashi E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090215
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/metabolism
MH  - Female
MH  - Nerve Fibers, Unmyelinated/*physiology/ultrastructure
MH  - *Nerve Regeneration
MH  - *Physical Conditioning, Animal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/antagonists & inhibitors/*metabolism
MH  - Signal Transduction
MH  - Spinal Cord/*physiology/ultrastructure
MH  - Spinal Cord Injuries/metabolism/*physiopathology
EDAT- 2009/02/19 09:00
MHDA- 2009/04/17 09:00
CRDT- 2009/02/19 09:00
PHST- 2009/02/09 00:00 [received]
PHST- 2009/02/10 00:00 [accepted]
PHST- 2009/02/19 09:00 [entrez]
PHST- 2009/02/19 09:00 [pubmed]
PHST- 2009/04/17 09:00 [medline]
AID - S0006-291X(09)00298-8 [pii]
AID - 10.1016/j.bbrc.2009.02.043 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2009 Apr 10;381(3):339-44. doi: 
      10.1016/j.bbrc.2009.02.043. Epub 2009 Feb 15.